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The Correlation Between the Natural Course, Pathologic Properties With Ki-67 Expression in Lung Adenocarcinoma Presenting As Ground-Glass Nodules

Overview
Journal Cancer Med
Specialty Oncology
Date 2024 Nov 5
PMID 39498818
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Abstract

Background: With the increasing use of lung cancer screening, the detection of ground glass nodules (GGNs) has risen. However, the natural course of GGNs and their relationship to pathologic features remains unclear. Differentiating between invasive and pre-invasive lesions based on GGN growth may improve clinical intervention timing. Ki-67, a proliferation marker, holds value in assessing tumor malignancy. This study analyzes the association between GGN growth, pathology, and Ki-67 expression to provide new insights into early-stage lung cancer management.

Methods: We retrospectively evaluated 183 GGNs with at least two preoperative CT scans. Nodule location, type, natural course, and volume doubling time (VDT) were compared between invasive adenocarcinoma (IAC) and pre-IAC groups. We also assessed differences in Ki-67 expression and correlated VDT with Ki-67 levels.

Results: A total of 183 nodules were finally included; gender, nodule location, smoking history, and duration of follow-up did not differ between the IAC group and the pre-IAC group, whereas age was statistically different between the two groups. Of the 183 nodules, 52 showed growth and the predominant pathologic type was IAC, these IACs showed more PSN in nodule type, while the IAC group showed more significant differences in nodule type, nodules growth, and VDT than the pre-IAC group. There were also differences in pathologic type and VDT between different Ki-67 expression groups, and Ki-67 expression gradually increased as VDT decreased.

Conclusion: Lung adenocarcinoma (LUAD) presenting as GGNs exhibit distinct natural courses among pathologic subtypes. VDT effectively distinguishes these growth characteristics, with IACs showing shorter VDT. The significant correlation between VDT and Ki-67 expression suggests that combining these parameters may provide valuable insights into the biological behavior and invasiveness of LUAD.

References
1.
Nagao K, Yamamoto Y, Hara T, Komatsu H, Inoue R, Matsuda K . Ki67 and BUBR1 may discriminate clinically insignificant prostate cancer in the PSA range <4 ng/ml. Jpn J Clin Oncol. 2011; 41(4):555-64. DOI: 10.1093/jjco/hyq233. View

2.
Morimoto R, Satoh F, Murakami O, Suzuki T, Abe T, Tanemoto M . Immunohistochemistry of a proliferation marker Ki67/MIB1 in adrenocortical carcinomas: Ki67/MIB1 labeling index is a predictor for recurrence of adrenocortical carcinomas. Endocr J. 2008; 55(1):49-55. DOI: 10.1507/endocrj.k07-079. View

3.
FERNANDEZ E, Sesterhenn I, McCarthy W, Mostofi F, Moul J . Proliferating cell nuclear antigen expression to predict occult disease in clinical stage I nonseminomatous testicular germ cell tumors. J Urol. 1994; 152(4):1133-8. DOI: 10.1016/s0022-5347(17)32522-3. View

4.
Saghir Z, Dirksen A, Ashraf H, Bach K, Brodersen J, Clementsen P . CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax. 2012; 67(4):296-301. DOI: 10.1136/thoraxjnl-2011-200736. View

5.
Belkin A, Freynd G . [A new one in the lung and pleura neoplasms classification (WHO, 2021, 5th edition)]. Arkh Patol. 2022; 84(5):28-34. DOI: 10.17116/patol20228405128. View