A 14-Year Analysis of Breast Cancer Risk Factors and Its Determinants of Mortality in Rural Southwestern Nigeria

Overview

Journal Clin Med Insights Oncol

Publisher Sage Publications

Specialty Oncology

Date 2024 Nov 5

PMID 39497926

Authors

Azeez Oyemomi Ibrahim

Adetunji Omonijo

Tosin Anthony Agbesanwa

Ayodele Kamal Alabi

Olayide Toyin Elegbede

Kolawole Michael Olusuyi

Musah Yusuf

Eniola Ayoyemi Afolabi-Obe

Olagoke Erinomo

Olakunle Fatai Babalola

Henry Abiyere

Olayinka Tesleem Orewole

Shuaib Kayode Aremu

Affiliations

Soon will be listed here.

Abstract

Background: Research on breast cancer risk factors and mortality is gaining recognition and attention globally; there is need to add more information on its determinants among patients admitted in hospital. Some studies on risk factors and mortality of breast cancer in Nigeria hospitals conducted in the urban and suburban areas have been documented. Therefore, an addition of a study conducted in the setting of a rural health institution is necessary. This study assessed the risk factors and determinants of mortality among patients admitted for breast cancer in rural Southwestern Nigeria.

Methods: A retrospective observational study was conducted on 260 patients who were admitted for breast cancer between January 2010 and December 2023 using a data form and a standardized information form. The data were analyzed using SPSS version 22.0. The risk factors and the determinants of mortality of patients with breast cancer were identified using multivariate regression model.

Results: The breast cancer risk factors were old age, family history, tobacco smoking, combined oral contraceptives, and hormonal therapy use. The case fatality rate was 38.1%, and its determinants of mortality were patients who were older (adjusted odds ratio [AOR], 1.956; 95% confidence interval [CI]:1.341-4.333), obese (AOR, 2.635; 95% CI: 1.485-6.778), stage IV (AOR, 1.895; 95% CI: 1.146-8.9742), mastectomy (AOR, 2.512; 95% CI: 1.003-6.569), discontinued adjuvant chemotherapy (AOR, 1.785; 95% CI: 1.092-4.6311), and yet to commence adjuvant chemotherapy (AOR, 2.568; 95% CI: 1.367-5.002).

Conclusion: The study revealed that patients with breast cancer were associated with high mortality. Sustained health education to promote early diagnosis, managed co-morbidities, and access to treatment may contribute to reduction in breast cancer mortality in rural Nigeria.

References

Schulz M, Spors E, Bates K, Michael S . Spatial Analysis of Breast Cancer Mortality Rates in a Rural State. Prev Chronic Dis. 2022; 19:E65. PMC: 9616131. DOI: 10.5888/pcd19.220113. View

Dennis J, Ghadirian P, Little J, Lubinski J, Gronwald J, Kim-Sing C . Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast. 2010; 19(6):479-83. PMC: 3756317. DOI: 10.1016/j.breast.2010.05.009. View

Oldenburg R, Meijers-Heijboer H, Cornelisse C, Devilee P . Genetic susceptibility for breast cancer: how many more genes to be found?. Crit Rev Oncol Hematol. 2007; 63(2):125-49. DOI: 10.1016/j.critrevonc.2006.12.004. View

Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T . Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012; 62(4):220-41. DOI: 10.3322/caac.21149. View

Fink V, Jenkins C, Castilho J, Person A, Shepherd B, Grinsztejn B . Survival after cancer diagnosis in a cohort of HIV-positive individuals in Latin America. Infect Agent Cancer. 2018; 13:16. PMC: 5941620. DOI: 10.1186/s13027-018-0188-3. View

Allemani C, Weir H, Carreira H, Harewood R, Spika D, Wang X . Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 2014; 385(9972):977-1010. PMC: 4588097. DOI: 10.1016/S0140-6736(14)62038-9. View

Ohene-Yeboah M, Adjei E . Breast cancer in Kumasi, Ghana. Ghana Med J. 2012; 46(1):8-13. PMC: 3353503. View

Zeinomar N, Knight J, Genkinger J, Phillips K, Daly M, Milne R . Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC). Breast Cancer Res. 2019; 21(1):128. PMC: 6883541. DOI: 10.1186/s13058-019-1213-1. View

Peto R, Davies C, Godwin J, Gray R, Pan H, Clarke M . Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet. 2011; 379(9814):432-44. PMC: 3273723. DOI: 10.1016/S0140-6736(11)61625-5. View

10.

Cogliano V, Baan R, Straif K, Grosse Y, Lauby-Secretan B, El Ghissassi F . Preventable exposures associated with human cancers. J Natl Cancer Inst. 2011; 103(24):1827-39. PMC: 3243677. DOI: 10.1093/jnci/djr483. View

11.

DeSantis C, Ma J, Sauer A, Newman L, Jemal A . Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J Clin. 2017; 67(6):439-448. DOI: 10.3322/caac.21412. View

12.

Tiruneh M, Tesfaw A, Tesfa D . Survival and Predictors of Mortality among Breast Cancer Patients in Northwest Ethiopia: A Retrospective Cohort Study. Cancer Manag Res. 2021; 13:9225-9234. PMC: 8687444. DOI: 10.2147/CMAR.S339988. View

13.

von Elm E, Altman D, Egger M, Pocock S, Gotzsche P, Vandenbroucke J . The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007; 147(8):573-7. DOI: 10.7326/0003-4819-147-8-200710160-00010. View

14.

Yu K, Fan L, Qiu L, Ling H, Jiang Y, Shao Z . Influence of delayed initiation of adjuvant chemotherapy on breast cancer survival is subtype-dependent. Oncotarget. 2016; 8(28):46549-46556. PMC: 5542291. DOI: 10.18632/oncotarget.10551. View

15.

Ewertz M, Duffy S, Adami H, Kvale G, Lund E, Meirik O . Age at first birth, parity and risk of breast cancer: a meta-analysis of 8 studies from the Nordic countries. Int J Cancer. 1990; 46(4):597-603. DOI: 10.1002/ijc.2910460408. View

16.

Hopkins B, Goncalves M, Cantley L . Obesity and Cancer Mechanisms: Cancer Metabolism. J Clin Oncol. 2016; 34(35):4277-4283. PMC: 5562429. DOI: 10.1200/JCO.2016.67.9712. View

17.

Zhan Q, Fu J, Fu F, Zhang J, Wang C . Survival and time to initiation of adjuvant chemotherapy among breast cancer patients: a systematic review and meta-analysis. Oncotarget. 2018; 9(2):2739-2751. PMC: 5788675. DOI: 10.18632/oncotarget.23086. View

18.

Jara Sanchez C, Ruiz A, Martin M, Anton A, Munarriz B, Plazaola A . Influence of timing of initiation of adjuvant chemotherapy over survival in breast cancer: a negative outcome study by the Spanish Breast Cancer Research Group (GEICAM). Breast Cancer Res Treat. 2006; 101(2):215-23. DOI: 10.1007/s10549-006-9282-0. View

19.

Goldvaser H, Gal O, Rizel S, Hendler D, Neiman V, Shochat T . The association between smoking and breast cancer characteristics and outcome. BMC Cancer. 2017; 17(1):624. PMC: 5585941. DOI: 10.1186/s12885-017-3611-z. View

20.

Brewer H, Jones M, Schoemaker M, Ashworth A, Swerdlow A . Family history and risk of breast cancer: an analysis accounting for family structure. Breast Cancer Res Treat. 2017; 165(1):193-200. PMC: 5511313. DOI: 10.1007/s10549-017-4325-2. View