E2F3-dependent Activation of FAM111B Restricts Mouse Cytomegalovirus Replication in Primate Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2024 Nov 4

PMID 39494906

Authors

Eleonore Ostermann

Laura-Marie Luoto

Michaela Clausen

Sanamjeet Virdi

Wolfram Brune

Affiliations

Soon will be listed here.

Abstract

Importance: Viruses must counteract host cell defenses to facilitate viral replication. Viruses with a narrow host range, such as the cytomegaloviruses, are unable to counteract cellular defenses in cells of a foreign species. However, little is known about the cellular host range factors restricting cytomegalovirus replication. Here, we show that mouse cytomegalovirus (MCMV) induces the expression of the FAM111 proteases and that FAM111B, but not FAM111A that has previously been shown to restrict the replication of polyomavirus and orthopoxvirus host range mutants, acts as a cellular factor suppressing MCMV replication in human and rhesus monkey cells. The identification of FAM111B as a host range factor should provide new insight into the physiological functions of this poorly characterized protein.

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