Role of Cyclic Guanosine Monophosphate-adenosine Monophosphate Synthase-stimulator of Interferon Genes Pathway in Diabetes and Its Complications

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2024 Nov 4

PMID 39493568

Authors

Ming-Wei Fan

Jin-Lan Tian

Tan Chen

Can Zhang

Xin-Ru Liu

Zi-Jian Zhao

Shu-Hui Zhang

Yan Chen

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus (DM) is one of the major causes of mortality worldwide, with inflammation being an important factor in its onset and development. This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway in mediating inflammatory responses. Furthermore, it comprehensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM, diabetic gastroenteropathy, diabetic cardiomyopathy, non-alcoholic fatty liver disease, and other complications. Additionally, the role of cGAS-STING in autonomic dysfunction and intestinal dysregulation, which can lead to digestive complications, has been discussed. Altogether, this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.

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