Evolving Trends in Oral Cancer Burden in Europe: a Systematic Review

Overview

Journal Front Oncol

Specialty Oncology

Date 2024 Nov 4

PMID 39493458

Authors

Amr Sayed Ghanem

Hafsa Aijaz Memon

Attila Csaba Nagy

Affiliations

Soon will be listed here.

Abstract

Introduction: Oral cavity cancer (OCC), primarily oral squamous cell carcinoma (OSCC), is a growing concern in Europe, particularly among younger populations. Preventable lifestyle factors and social determinants of health contribute significantly to the disease burden. Limited access to healthcare and delayed diagnoses further complicate treatment and reduce survival rates.

Methods: This systematic literature review adhered to PRISMA guidelines to explore trends in OSCC epidemiology, etiology, diagnosis, treatment, and survival across Europe. A comprehensive search strategy using PubMed, GLOBOCAN data, and the EUROCARE-5 study identified relevant articles focusing on human populations in Europe with a primary interest in OSCC epidemiology. Only peer-reviewed publications in English with full-text access were included.

Results: This study investigated the burden of OSCC across Europe, revealing variations in incidence, mortality, and prognosis. Eastern and Central Europe displayed the highest burden. Males exhibited a significantly higher risk compared to females. Age-related disparities existed in life expectancy and time to achieve favorable outcomes. HPV emerged as a growing risk factor for oropharyngeal cancer. Public health strategies should target modifiable risk factors and improve early detection.

Conclusion: This review reveals concerning disparities in European OSCC. Region, sex, and age all influence burden and prognosis. Future research should focus on controlling risk factors and personalized medicine to optimize treatment. This will lead to a Europe with reduced OSCC incidence and demonstrably better patient outcomes.

Citing Articles

HPV Infection and Oral Microbiota: Interactions and Future Implications.

Xia Q, Pierson S Int J Mol Sci. 2025; 26(4).

PMID: 40003891 PMC: 11855562. DOI: 10.3390/ijms26041424.

Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders.

Lopez-Pintor R, Gonzalez-Serrano J, Vallina C, Ivaylova Serkedzhieva K, Virto L, Nuevo P Front Oral Health. 2025; 5():1525936.

PMID: 39839666 PMC: 11747469. DOI: 10.3389/froh.2024.1525936.

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