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Unraveling Pancreatic Cancer: Epidemiology, Risk Factors, and Global Trends

Overview
Journal Cureus
Date 2024 Nov 4
PMID 39493341
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Abstract

Pancreatic cancer is one of the most lethal malignancies, characterized by late diagnosis, rapid progression, and limited treatment options. This literature review comprehensively examines the epidemiology, risk factors, diagnostic challenges, treatment modalities, and prognosis of pancreatic cancer. It highlights the global disparities in incidence and outcomes, exploring the influence of socioeconomic, environmental, and genetic factors on disease progression. In addition, this review discusses recent advancements in diagnostic tools and treatment strategies, identifying gaps in current research and clinical practices. The synthesis aims to inform future research directions and policy-making efforts to reduce the global burden of pancreatic cancer and improve patient outcomes.

References
1.
Hosseini B, Hall A, Zendehdel K, Kromhout H, Onyije F, Moradzadeh R . Occupational Exposure to Carcinogens and Occupational Epidemiological Cancer Studies in Iran: A Review. Cancers (Basel). 2021; 13(14). PMC: 8305339. DOI: 10.3390/cancers13143581. View

2.
Ghiorzo P . Genetic predisposition to pancreatic cancer. World J Gastroenterol. 2014; 20(31):10778-89. PMC: 4138458. DOI: 10.3748/wjg.v20.i31.10778. View

3.
Principe D, Korc M, Kamath S, Munshi H, Rana A . Trials and tribulations of pancreatic cancer immunotherapy. Cancer Lett. 2021; 504:1-14. PMC: 7940598. DOI: 10.1016/j.canlet.2021.01.031. View

4.
Kandikattu H, Venkateshaiah S, Mishra A . Chronic Pancreatitis and the Development of Pancreatic Cancer. Endocr Metab Immune Disord Drug Targets. 2020; 20(8):1182-1210. PMC: 7577953. DOI: 10.2174/1871530320666200423095700. View

5.
Burkon P, Trna J, Slavik M, Nemecek R, Kazda T, Pospisil P . Stereotactic Body Radiotherapy (SBRT) of Pancreatic Cancer-A Critical Review and Practical Consideration. Biomedicines. 2022; 10(10). PMC: 9599229. DOI: 10.3390/biomedicines10102480. View