» Articles » PMID: 39490335

Update on PSMA-based Prostate Cancer Imaging

Overview
Journal Semin Nucl Med
Specialty Nuclear Medicine
Date 2024 Nov 3
PMID 39490335
Authors
Affiliations
Soon will be listed here.
Abstract

The increased use of prostate-specific membrane antigen (PSMA) based PET imaging for prostate cancer (Pca) detection has revolutionized the clinical management of Pca, with higher diagnostic sensitivity for extraprostatic disease and increasing clinical utility across different stages of the disease. The integration of PSMA PET imaging into clinical guidelines and consensus documents reflects its growing importance in the personalized management of Pca. This review of recent literature highlights the rapid evolution of PSMA PET into the mainstream of staging and restaging and the decreasing reliance on conventional imaging modalities. This comprehensive review serves as a resource for clinicians and researchers involved in the domains of Pca diagnosis and management.

Citing Articles

Comparison of Cu-DOTA-PSMA-3Q and Cu-NOTA-PSMA-3Q utilizing NOTA and DOTA as bifunctional chelators in prostate cancer: preclinical assessment and preliminary clinical PET/CT imaging.

Liu H, Zhang X, Zhang J, Pan Y, Wen H, Xu X Eur J Nucl Med Mol Imaging. 2025; .

PMID: 39954062 DOI: 10.1007/s00259-025-07131-3.


Diagnostic Ability of Quantitative Parameters of Whole-Body Bone SPECT/CT Using a Full-Ring 360° Cadmium-Zinc-Telluride Camera for Detecting Bone Metastasis in Patients with Prostate Cancer.

Yoo I, Hong S, Lee S, Yang H, Kim K, Kim S Diagnostics (Basel). 2024; 14(23).

PMID: 39682622 PMC: 11639772. DOI: 10.3390/diagnostics14232714.

References
1.
Emmett L, Tang R, Nandurkar R, Hruby G, Roach P, Watts J . 3-Year Freedom from Progression After Ga-PSMA PET/CT-Triaged Management in Men with Biochemical Recurrence After Radical Prostatectomy: Results of a Prospective Multicenter Trial. J Nucl Med. 2019; 61(6):866-872. DOI: 10.2967/jnumed.119.235028. View

2.
Hope T, Eiber M, Armstrong W, Juarez R, Murthy V, Lawhn-Heath C . Diagnostic Accuracy of 68Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection: A Multicenter Prospective Phase 3 Imaging Trial. JAMA Oncol. 2021; 7(11):1635-1642. PMC: 8446902. DOI: 10.1001/jamaoncol.2021.3771. View

3.
Woo S, Ghafoor S, Becker A, Han S, Wibmer A, Hricak H . Prostate-specific membrane antigen positron emission tomography (PSMA-PET) for local staging of prostate cancer: a systematic review and meta-analysis. Eur J Hybrid Imaging. 2021; 4(1):16. PMC: 8218057. DOI: 10.1186/s41824-020-00085-9. View

4.
Scharl S, Zamboglou C, Strouthos I, Farolfi A, Serani F, Lanzafame H . Salvage radiotherapy is effective in patients with PSMA-PET-negative biochemical recurrence- results of a retrospective study. Radiother Oncol. 2023; 184:109678. DOI: 10.1016/j.radonc.2023.109678. View

5.
Hofman M, Emmett L, Sandhu S, Iravani A, Joshua A, Goh J . [Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial. Lancet. 2021; 397(10276):797-804. DOI: 10.1016/S0140-6736(21)00237-3. View