Leukocytes Telomere Length As a Biomarker of Adverse Drug Reactions Induced by Osimertinib in Advanced Non-small Cell Lung Cancer

Overview

Journal Sci Rep

Specialty Science

Date 2024 Nov 3

PMID 39489788

Authors

Narumol Trachu

Thanyanan Reungwetwattana

Jennis Meanwatthana

Chonlaphat Sukasem

Teerapat Majam

Wacharapol Saengsiwaritt

Jiraphun Jittikoon

Wanvisa Udomsinprasert

Affiliations

Soon will be listed here.

Abstract

This study aimed to measure relative telomere length (RTL) in blood leukocytes of advanced-stage NSCLC patients either with or without Osimertinib-induced ADRs and determine whether RTL could serve as a biomarker of Osimertinib-induced ADRs. Blood leukocytes RTL were measured in 63 advanced-stage NSCLC patients and 62 age-matched healthy controls using real-time polymerase chain reaction. In patients with advanced-stage NSCLC, RTL was significantly shorter than that in healthy controls (P < 0.001). Compared to patients without ADRs and those with mild/moderate ADRs, patients with severe ADRs exhibited significantly decreased RTL (P < 0.001, P < 0.001, respectively). ROC curve analysis uncovered a diagnostic value of RTL as a biomarker of Osimertinib-induced ADRs (AUC = 1.000, P < 0.001). Kaplan-Meier analysis revealed a significant association between shorter RTL and increased cumulative incidence of Osimertinib-induced ADRs in patients with advanced-stage NSCLC (P < 0.001). Shorter RTL in blood leukocytes would reflect the occurrence of Osimertinib-induced ADRs and might emerge as a promising biomarker for identifying advanced-stage NSCLC patients who are at risk of experiencing Osimertinib-induced ADRs, particularly those with severe ADRs.

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