Zéro Allergie Research Clinic: a Clinical and Research Initiative in Oral Immunotherapy for Managing IgE-mediated Food Allergy

Overview

Journal Allergy Asthma Clin Immunol

Specialty Allergy & Immunology

Date 2024 Nov 3

PMID 39488713

Authors

Benedicte L Tremblay

Philippe Begin

Frederique Gagnon-Brassard

Anne-Marie Boucher-Lafleur

Marie-Eve Lavoie

Anne-Marie Madore

Sarah Lavoie

Cloe Rochefort-Beaudoin

Claudia Nuncio-Naud

Charles Morin

Guy Parizeault

Catherine Laprise

Affiliations

Soon will be listed here.

Abstract

Background And Methods: The Zéro allergie research clinic (Saguenay, Canada) is a clinical and research initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA and 27 non-allergic siblings were recruited to date in the Zéro allergie cohort (ZAC) to better understand biological mechanisms underlying FA and OIT prognosis. The primary aims are to (a) better understand the genetic, epigenetic, transcriptomic, metabolomic, and microbial diversity associated with FA; (b) establish the multi-omics and microbial diversity profiles of children following OIT to identify predictive prognosis biomarkers, (c) make OIT more accessible to the population of the Saguenay-Lac-Saint-Jean region, and (d) build a biobank of data and biological material.

Results: The ZAC constitutes a unique and rich biobank of biological samples (blood, buccal swabs, microbiota samples [intestinal, buccal, nasal, and cutaneous]) combined with clinical data and more than 75 phenotypic characteristics.

Conclusions: This represents an innovative interdisciplinary initiative by researchers, allergists, and paediatricians to make FA care accessible to a greater number of children with IgE-mediated FA. Ultimately, it will contribute to provide more accessible treatment options with greater chances of success through a better understanding of the biological nature of FA and OIT.

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