Comparative Analysis of Vitamin D, Folic Acid, and Trace Minerals Levels in Various Stages of Invasive Ductal Breast Cancer

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Nov 1

PMID 39483603

Authors

Vemuri Helena

Suresh Arumugam

Natrajan Muninathan

Kuppusamy Baskaran

Amena Tasneem

Affiliations

Soon will be listed here.

Abstract

Background: Invasive ductal carcinoma (IDC) is one of the most commonly diagnosed subtypes of breast cancer, representing the majority of breast cancer cases. This study investigates the levels of vitamin D, folic acid, and antioxidant minerals (zinc (Zn), copper (Cu), and magnesium (Mg)) in IDC patients across different disease stages to explore their potential roles in disease progression.

Methods: We analyzed a cohort of 150 female patients with IDC, aged between 30 and 67 years (51 ± 15.5 years). Blood samples were collected to measure levels of vitamin D, folic acid, Cu, Mg, and Zn. Patients were categorized into Stage 1 to Stage 4 of cancer. Variations in nutrient levels across these stages were statistically assessed using ANOVA and post-hoc tests.

Results: The study results revealed varying levels of key nutrients across different stages of the disease. Vitamin D levels averaged 17.7 ng/mL, with higher concentrations in early-stage patients, indicating a possible correlation with disease severity. Folic acid levels had a mean of 12.2 ng/mL, showing a decline in later stages, potentially linking it to cancer progression. Copper levels averaged 161.3μg/dL, peaking at 170μg/dL in Stage 3, suggesting a connection with cancer aggressiveness. Magnesium levels, with an average of 1.4 mg/dL, dropped notably to 0.6 mg/dL by Stage 4, highlighting its possible involvement in disease progression. Zinc levels averaged 69.4 μg/dL, with a significant decrease in advanced stages, emphasizing its importance for immune function and cellular health.

Conclusion: The study demonstrates significant variations in the levels of vitamin D, folic acid, and antioxidant minerals across different stages of IDC. These nutrients may influence cancer progression, underscoring the potential benefits of nutritional assessments and interventions in managing IDC.

References

Moukayed M, Grant W . Molecular link between vitamin D and cancer prevention. Nutrients. 2013; 5(10):3993-4021. PMC: 3820056. DOI: 10.3390/nu5103993. View

Lelievre P, Sancey L, Coll J, Deniaud A, Busser B . The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy. Cancers (Basel). 2020; 12(12). PMC: 7760327. DOI: 10.3390/cancers12123594. View

Gombart A, Pierre A, Maggini S . A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020; 12(1). PMC: 7019735. DOI: 10.3390/nu12010236. View

Henn M, Martin-Gorgojo V, Martin-Moreno J . Vitamin D in Cancer Prevention: Gaps in Current Knowledge and Room for Hope. Nutrients. 2022; 14(21). PMC: 9657468. DOI: 10.3390/nu14214512. View

Torres A, Cameselle C, Otero P, Simal-Gandara J . The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review. Nutrients. 2024; 16(5). PMC: 10934904. DOI: 10.3390/nu16050573. View

Skrajnowska D, Bobrowska-Korczak B . Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms. Nutrients. 2019; 11(10). PMC: 6835436. DOI: 10.3390/nu11102273. View

Kim D, Shinde S, Ghodake G . Colorimetric detection of magnesium (II) ions using tryptophan functionalized gold nanoparticles. Sci Rep. 2017; 7(1):3966. PMC: 5479790. DOI: 10.1038/s41598-017-04359-4. View

Maggini S, Pierre A, Calder P . Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients. 2018; 10(10). PMC: 6212925. DOI: 10.3390/nu10101531. View

Makki J . Diversity of Breast Carcinoma: Histological Subtypes and Clinical Relevance. Clin Med Insights Pathol. 2016; 8:23-31. PMC: 4689326. DOI: 10.4137/CPath.S31563. View

10.

Fernandez-Barral A, Bustamante-Madrid P, Ferrer-Mayorga G, Barbachano A, Larriba M, Munoz A . Vitamin D Effects on Cell Differentiation and Stemness in Cancer. Cancers (Basel). 2020; 12(9). PMC: 7563562. DOI: 10.3390/cancers12092413. View

11.

Deheinzelin D, Negri E, Tucci M, SALEM M, da Cruz V, Oliveira R . Hypomagnesemia in critically ill cancer patients: a prospective study of predictive factors. Braz J Med Biol Res. 2000; 33(12):1443-8. DOI: 10.1590/s0100-879x2000001200007. View

12.

Tang X, Yan Z, Miao Y, Ha W, Li Z, Yang L . Copper in cancer: from limiting nutrient to therapeutic target. Front Oncol. 2023; 13:1209156. PMC: 10327296. DOI: 10.3389/fonc.2023.1209156. View

13.

Thabet R, Alessa R, Al-Smadi Z, Alshatnawi B, Amayreh B, Al-Dwaaghreh R . Folic acid: friend or foe in cancer therapy. J Int Med Res. 2024; 52(1):3000605231223064. PMC: 10935767. DOI: 10.1177/03000605231223064. View

14.

Basten G, Duthie S, Pirie L, Vaughan N, Hill M, Powers H . Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Br J Cancer. 2006; 94(12):1942-7. PMC: 2361358. DOI: 10.1038/sj.bjc.6603197. View

15.

Gnagnarella P, Muzio V, Caini S, Raimondi S, Martinoli C, Chiocca S . Vitamin D Supplementation and Cancer Mortality: Narrative Review of Observational Studies and Clinical Trials. Nutrients. 2021; 13(9). PMC: 8466115. DOI: 10.3390/nu13093285. View

16.

Dhawan D, Chadha V . Zinc: a promising agent in dietary chemoprevention of cancer. Indian J Med Res. 2011; 132:676-82. PMC: 3102454. View

17.

Neethi H, Patil S, Rao R . Estimation of serum copper and zinc levels in oral submucous fibrosis: an atomic absorption spectroscopic study. J Contemp Dent Pract. 2014; 14(5):801-5. DOI: 10.5005/jp-journals-10024-1406. View

18.

Negri M, Gentile A, de Angelis C, Monto T, Patalano R, Colao A . Vitamin D-Induced Molecular Mechanisms to Potentiate Cancer Therapy and to Reverse Drug-Resistance in Cancer Cells. Nutrients. 2020; 12(6). PMC: 7353389. DOI: 10.3390/nu12061798. View

19.

Ashique S, Kumar S, Hussain A, Mishra N, Garg A, Gowda B . A narrative review on the role of magnesium in immune regulation, inflammation, infectious diseases, and cancer. J Health Popul Nutr. 2023; 42(1):74. PMC: 10375690. DOI: 10.1186/s41043-023-00423-0. View

20.

Workeneh B, Uppal N, Jhaveri K, Rondon-Berrios H . Hypomagnesemia in the Cancer Patient. Kidney360. 2022; 2(1):154-166. PMC: 8785729. DOI: 10.34067/KID.0005622020. View