Mesenchymal Stem Cell-derived Extracellular Vesicles in Systemic Sclerosis: Role and Therapeutic Directions

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2024 Nov 1

PMID 39483335

Authors

Xuan Wang

Jiaying Guo

Qiangfu Dai

Affiliations

Soon will be listed here.

Abstract

Systemic sclerosis (SSc) is a complex autoimmune disease with clinical symptoms of vascular damage, immune disorders, and fibrosis, presenting significant treatment challenges and limited therapeutic options. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been demonstrated in numerous studies as more effective than MSCs in treating autoimmune diseases. Recent studies demonstrate that MSC-EVs can significantly ameliorate the symptoms of SSc and mitigate pathological changes such as vascular injury, immune dysregulation, and fibrosis. These findings underscore the promising therapeutic potential of MSC-EVs in the treatment of SSc. MSC-EVs promote angiogenesis, modulate immune dysfunction, and combat fibrosis. This article summarizes the therapeutic applications and possible mechanisms of MSC-EVs for SSc, thereby offering a novel therapeutic direction for the treatment of SSc.

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