Prevalence of Non-smoking Chronic Obstructive Pulmonary Disease and Its Risk Factors in China: a Systematic Review and Meta-analysis

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2024 Oct 31

PMID 39478509

Authors

Yue Zhang

Xiaoyan Gai

Hongling Chu

Jingge Qu

Liang Li

Yongchang Sun

Affiliations

Soon will be listed here.

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent chronic disorder in China, impacting a significant proportion of individuals aged > 40 years. In China, the prevalence of and risk factors for COPD among non-smokers remain largely unexplored. In this study, we aimed to determine the prevalence of COPD in non-smokers within the Chinese population and identify potential risk factors associated with COPD in non-smokers.

Methods: Web of Science, PubMed, Embase, Chinese WanFang, Chinese China National Knowledge Infrastructure, and Weipu databases from inception to August 5, 2024, were searched. Studies reporting the percentage of never-smokers among those diagnosed with COPD and investigations exploring the risk factors associated with COPD in never-smokers in China were examined. Summary proportions and odds ratios (OR), along with their corresponding 95% confidence intervals (95% CI), were measured.

Results: In total, 112 investigations with 491,812 participants were included. The percentage of never-smokers in people with COPD was 41.1% (95% CI: 37.5-44.6%). The prevalence of never-smokers among males diagnosed with COPD was 22.3% (95% CI: 18.8-25.7%), which differed from that among women (81.3%, 95% CI: 75.3-87.2%). The results showed an association between the utilization of biomass fuel and the occurrence of COPD in never-smokers (OR: 1.25, 95% CI: 1.06-1.44). Among never-smokers, the data showed a close association between being underweight (OR: 1.89, 95% CI: 1.78-2.00), tuberculosis history (OR: 1.71, 95% CI: 1.53-1.88) and COPD. Never-smokers living in rural areas or those with low educational status were more susceptible to COPD.

Conclusion: This review confirmed the highly different proportions of never-smokers among male and female patients with COPD.

Trial Registration: PROSPERO: CRD42023420786.

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