A 3D Genome View of Colon Cancer Initiation

Overview

Journal Nat Cancer

Specialty Oncology

Date 2024 Oct 31

PMID 39478116

Authors

Adi Danieli-Mackay

Argyris Papantonis

Affiliations

Soon will be listed here.

References

Danieli A, Papantonis A . Spatial genome architecture and the emergence of malignancy. Hum Mol Genet. 2020; 29(R2):R197-R204. DOI: 10.1093/hmg/ddaa128. View

Dubois F, Sidiropoulos N, Weischenfeldt J, Beroukhim R . Structural variations in cancer and the 3D genome. Nat Rev Cancer. 2022; 22(9):533-546. PMC: 10423586. DOI: 10.1038/s41568-022-00488-9. View

Wang X, Yue F . Hijacked enhancer-promoter and silencer-promoter loops in cancer. Curr Opin Genet Dev. 2024; 86:102199. DOI: 10.1016/j.gde.2024.102199. View

Zhu Y, Lee H, White S, Weimer A, Monte E, Horning A . Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis. Nat Cancer. 2024; 5(11):1697-1712. PMC: 11584406. DOI: 10.1038/s43018-024-00823-z. View

Goel V, Hansen A . The macro and micro of chromosome conformation capture. Wiley Interdiscip Rev Dev Biol. 2020; 10(6):e395. PMC: 8236208. DOI: 10.1002/wdev.395. View

Gryder B, Pomella S, Sayers C, Wu X, Song Y, Chiarella A . Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019; 51(12):1714-1722. PMC: 6886578. DOI: 10.1038/s41588-019-0534-4. View

Liu Y, Guo B, Aguilera-Jimenez E, Chu V, Zhou J, Wu Z . Chromatin Looping Shapes KLF5-Dependent Transcriptional Programs in Human Epithelial Cancers. Cancer Res. 2020; 80(24):5464-5477. PMC: 7787512. DOI: 10.1158/0008-5472.CAN-20-1287. View

Sanalkumar R, Dong R, Lee L, Xing Y, Iyer S, Letovanec I . Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity. Sci Adv. 2023; 9(13):eabo3789. PMC: 10718307. DOI: 10.1126/sciadv.abo3789. View

Chakraborty C, Nissen I, Vincent C, Hagglund A, Hornblad A, Remeseiro S . Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication. Nat Commun. 2023; 14(1):6446. PMC: 10576091. DOI: 10.1038/s41467-023-41919-x. View

10.

Madsen J, Madsen M, Rauch A, Traynor S, Van Hauwaert E, Haakonsson A . Highly interconnected enhancer communities control lineage-determining genes in human mesenchymal stem cells. Nat Genet. 2020; 52(11):1227-1238. DOI: 10.1038/s41588-020-0709-z. View

11.

Murphy D, Salataj E, Di Giammartino D, Rodriguez-Hernaez J, Kloetgen A, Garg V . 3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages. Nat Struct Mol Biol. 2023; 31(1):125-140. PMC: 10897904. DOI: 10.1038/s41594-023-01130-4. View

12.

Loven J, Hoke H, Lin C, Lau A, Orlando D, Vakoc C . Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 2013; 153(2):320-34. PMC: 3760967. DOI: 10.1016/j.cell.2013.03.036. View

13.

Xie T, Danieli-Mackay A, Buccarelli M, Barbieri M, Papadionysiou I, DAlessandris Q . Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs. Nat Commun. 2024; 15(1):3905. PMC: 11082206. DOI: 10.1038/s41467-024-48053-2. View