Clinical Utility of Anti-Müllerian Hormone in Female Children and Adolescents

Overview

Journal Hormones (Athens)

Specialty Endocrinology

Date 2024 Oct 31

PMID 39477856

Authors

Effrosyni Birbas

Anastasia Vatopoulou

Theofilos Kanavos

Kyriakos Birmpas

Chara Skentou

Athanasios Zikopoulos

Fani Gkrozou

Affiliations

Soon will be listed here.

Abstract

Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that belongs to the transforming growth factor beta superfamily and plays essential roles in sexual differentiation and folliculogenesis. In the male embryo, AMH is produced by the Sertoli cells and induces the involution of the Müllerian ducts. In females, AMH is predominately produced by the granulosa cells of growing preantral and small antral follicles and regulates follicular maturation. Many recent studies have highlighted the significant role of this hormone in the diagnostic approach to female children and adolescents with various disorders that affect ovarian development and function. AMH is considered a valuable diagnostic tool in the management of female pediatric patients with conditions such as polycystic ovary syndrome, precocious puberty, ovarian tumors, differences in sex development, and premature ovarian insufficiency. Standardization of AMH assays, internationally approved reference values based on age and pubertal stage, and widespread availability of the test could further upgrade the clinical utility of AMH, rendering it a valuable tool in the armamentarium of physicians involved in the care of female children and adolescents, and promote future research.

Citing Articles

Diagnosis and Treatment of Adolescent Polycystic Ovary syndrome:A Review.

Zhang Y, Yang K, Fan T, Zheng D, Liu H Int J Womens Health. 2025; 17:459-474.

PMID: 39995885 PMC: 11847718. DOI: 10.2147/IJWH.S506498.

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