Effect of Combined Probiotics and Doxycycline Therapy on the Gut-skin Axis in Rosacea

Overview

Journal mSystems

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Oct 30

PMID 39475254

Authors

Jie Yu

Yan Duan

Meng Zhang

Qi Li

Miao Cao

Weixin Song

Feiyan Zhao

Lai-Yu Kwok

Heping Zhang

Ruiya Li

Zhihong Sun

Affiliations

Soon will be listed here.

Abstract

Importance: This research elucidates rosacea management with novel insights into probiotic use alongside doxycycline, showing dual benefits in symptom relief and inflammation reduction in patients. The study maps probiotic-induced shifts in gut and skin microbiota, underscoring microbial shifts correlating with skin health improvements. Crucially, it deciphers the gut-skin axis modulation by probiotics, proposing a method to curb antibiotic resistance in rosacea therapies. This study furnishes robust evidence for probiotics in rosacea, advancing our grasp of the gut-skin relationship.

References

Li Z, Ju Y, Xia J, Zhang Z, Zhen H, Tong X . Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat-Specific Microbiome Diversity and Function. Adv Sci (Weinh). 2023; 10(28):e2300050. PMC: 10558695. DOI: 10.1002/advs.202300050. View

Deng Z, Chen M, Liu Y, Xu S, Ouyang Y, Shi W . A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea. EMBO Mol Med. 2021; 13(5):e13560. PMC: 8103105. DOI: 10.15252/emmm.202013560. View

Li A, Fang R, Mao X, Sun Q . Photodynamic therapy in the treatment of rosacea: A systematic review. Photodiagnosis Photodyn Ther. 2022; 38:102875. DOI: 10.1016/j.pdpdt.2022.102875. View

Liu Y, Liu Y, Du Z, Zhang L, Chen J, Shen Z . Skin microbiota analysis-inspired development of novel anti-infectives. Microbiome. 2020; 8(1):85. PMC: 7275423. DOI: 10.1186/s40168-020-00866-1. View

Sanders M, Merenstein D, Reid G, Gibson G, Rastall R . Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol. 2019; 16(10):605-616. DOI: 10.1038/s41575-019-0173-3. View

Lebeer S, Oerlemans E, Claes I, Henkens T, Delanghe L, Wuyts S . Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli. Cell Rep Med. 2022; 3(2):100521. PMC: 8861818. DOI: 10.1016/j.xcrm.2022.100521. View

Mars R, Yang Y, Ward T, Houtti M, Priya S, Lekatz H . Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome. Cell. 2020; 182(6):1460-1473.e17. PMC: 8109273. DOI: 10.1016/j.cell.2020.08.007. View

Chen L, Wang D, Garmaeva S, Kurilshikov A, Vich Vila A, Gacesa R . The long-term genetic stability and individual specificity of the human gut microbiome. Cell. 2021; 184(9):2302-2315.e12. DOI: 10.1016/j.cell.2021.03.024. View

Yu Y, Dunaway S, Champer J, Kim J, Alikhan A . Changing our microbiome: probiotics in dermatology. Br J Dermatol. 2019; 182(1):39-46. DOI: 10.1111/bjd.18088. View

10.

Stamu-OBrien C, Jafferany M, Carniciu S, Abdelmaksoud A . Psychodermatology of acne: Psychological aspects and effects of acne vulgaris. J Cosmet Dermatol. 2020; 20(4):1080-1083. DOI: 10.1111/jocd.13765. View

11.

Miller C, Holm H, Horstmann L, George J, Fredricks H, Van Mooy B . Coordinated transformation of the gut microbiome and lipidome of bowhead whales provides novel insights into digestion. ISME J. 2019; 14(3):688-701. PMC: 7031289. DOI: 10.1038/s41396-019-0549-y. View

12.

Brody H . The gut microbiome. Nature. 2020; 577(7792):S5. DOI: 10.1038/d41586-020-00194-2. View

13.

Kang D, Li F, Kirton E, Thomas A, Egan R, An H . MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies. PeerJ. 2019; 7:e7359. PMC: 6662567. DOI: 10.7717/peerj.7359. View

14.

Hendrickson R, Urbaniak C, Minich J, Aronson H, Martino C, Stepanauskas R . Clean room microbiome complexity impacts planetary protection bioburden. Microbiome. 2021; 9(1):238. PMC: 8643001. DOI: 10.1186/s40168-021-01159-x. View

15.

Wang L, Xu Y, Chu C, Jing Z, Chen Y, Zhang J . Facial Skin Microbiota-Mediated Host Response to Pollution Stress Revealed by Microbiome Networks of Individual. mSystems. 2021; 6(4):e0031921. PMC: 8407115. DOI: 10.1128/mSystems.00319-21. View

16.

Daou H, Paradiso M, Hennessy K, Seminario-Vidal L . Rosacea and the Microbiome: A Systematic Review. Dermatol Ther (Heidelb). 2020; 11(1):1-12. PMC: 7859152. DOI: 10.1007/s13555-020-00460-1. View

17.

Zhang M, Zheng Y, Sun Z, Cao C, Zhao W, Liu Y . Change in the Gut Microbiome and Immunity by Lacticaseibacillus rhamnosus Probio-M9. Microbiol Spectr. 2023; :e0360922. PMC: 10100958. DOI: 10.1128/spectrum.03609-22. View

18.

Sood S, Jafferany M, Kumar S . Depression, psychiatric comorbidities, and psychosocial implications associated with acne vulgaris. J Cosmet Dermatol. 2020; 19(12):3177-3182. DOI: 10.1111/jocd.13753. View

19.

Sanchez-Pellicer P, Eguren-Michelena C, Garcia-Gavin J, Llamas-Velasco M, Navarro-Moratalla L, Nunez-Delegido E . Rosacea, microbiome and probiotics: the gut-skin axis. Front Microbiol. 2024; 14:1323644. PMC: 10800857. DOI: 10.3389/fmicb.2023.1323644. View

20.

Lu Q, Stappenbeck T . Local barriers configure systemic communications between the host and microbiota. Science. 2022; 376(6596):950-955. DOI: 10.1126/science.abo2366. View