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Considerations on Multimorbidity and Frailty in Inflammatory Bowel Diseases

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Date 2024 Oct 30
PMID 39475079
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Abstract

There are growing numbers of older people with inflammatory bowel diseases [IBD]. These older patients are more likely to have other comorbidities and polypharmacy, which can make recognizing and treating IBD complex. Frailty is a newer concept in the IBD field, and we are beginning to recognize the importance of this as a marker of biological age and its association with risk of adverse IBD-related outcomes. In this review article we aim to provide practical insight into the specific challenges facing older patients and their clinicians at each stage of the patient journey. We also discuss the latest understanding of the impact of frailty for these patients with IBD and highlight areas for future research.

References
1.
Zammarchi I, Lanzarotto F, Cannatelli R, Munari F, Benini F, Pozzi A . Elderly-onset vs adult-onset ulcerative colitis: a different natural history?. BMC Gastroenterol. 2020; 20(1):147. PMC: 7216336. DOI: 10.1186/s12876-020-01296-x. View

2.
Huang X, Xiao M, Jiang B, Wang X, Tang X, Xu X . Prevalence of frailty among patients with inflammatory bowel disease and its association with clinical outcomes: a systematic review and meta-analysis. BMC Gastroenterol. 2022; 22(1):534. PMC: 9773593. DOI: 10.1186/s12876-022-02620-3. View

3.
Cristina M, Spagnolo A, Giribone L, Demartini A, Sartini M . Epidemiology and Prevention of Healthcare-Associated Infections in Geriatric Patients: A Narrative Review. Int J Environ Res Public Health. 2021; 18(10). PMC: 8156303. DOI: 10.3390/ijerph18105333. View

4.
Desai A, Zator Z, de Silva P, Nguyen D, Korzenik J, Yajnik V . Older age is associated with higher rate of discontinuation of anti-TNF therapy in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2012; 19(2):309-15. PMC: 4345352. DOI: 10.1002/ibd.23026. View

5.
Saad Alshahrani A, Mohammad D, Attieh Alzahrani M, Narula N . Vedolizumab does not increase risk of clostridium difficile infection in patients with inflammatory bowel disease using vedolizumab: A retrospective cohort study. Saudi Pharm J. 2023; 31(9):101736. PMC: 10448164. DOI: 10.1016/j.jsps.2023.101736. View