Bibliometric and Visualized Analysis on Global Trends and Hotspots of TAK1 in Regulated Cell Death: 1999 to 2024

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Oct 30

PMID 39474417

Authors

Kun Huang

Ye He

Hao Wan

Xiao-Xia Ban

Xin-Yu Chen

Xi-Min Hu

Xin-Xing Wan

Rui Lu

Qi Zhang

Kun Xiong

Affiliations

Soon will be listed here.

Abstract

Background: Regulated cell death (RCD) is a genetically controlled form of cell death that plays an important role in organogenesis, tissue remodeling, and pathogenesis of cancers. Transforming growth factor-beta-activation kinase 1 (TAK1) is a member of the serine/threonine protein kinase family, which can respond to internal and external stimuli and participate in inflammatory responses through multiple signaling pathways and cellular processes. In the last two decades, the regulatory roles of TAK1 at the crossroads of multiple RCD pathways, including apoptosis, necroptosis, pyroptosis, and PANoptosis were revealed by 801 articles retrieved from the Web of Science Core Collection database. To analyze global research trends and hotspots concerning the role of TAK1 in RCD, the bibliometric and visualized analysis were applied in the current study.

Methods: The data for this bibliometrics study were retrieved from the Web of Science Core Collection database. The search formula was (TS=(Apoptosis) OR TS=(pyroptosis) OR TS=(Necroptosis) OR TS=(PANoptosis) OR TS=(Autophagy) OR TS=(Ferroptosis) OR TS=(cuproptosis)) AND ((TS=(TAK1)) OR TS=(MAP3K7)). The co-occurrence and co-cited analysis on basic bibliometric parameters were conducted by VOSviewer. The dual-map overlay of journals, citation bursts, keyword timelines, and keyword bursts were analyzed by CiteSpace.

Results: A total of 801 articles from 46 countries have been included in the analysis. The number of publications demonstrates a consistent increase from 1999 to 2024. The primary research institutions driving this field are Osaka University Notably, the Journal of Biological Chemistry stands out as the most popular journal in this domain. These publications collectively involve contributions from 4663 authors, with Jun Tsuji emerging as a prolific author. Jun Tsuji also gains the highest co-citation frequency. Emerging research hotspots are encapsulated by keywords, including apoptosis, NF-κB, inflammation, autophagy, and TNFα.

Conclusion: This is the first bibliometric and visualized study to analyze the global trends and hotspots of TAK1 in RCD. Based on the analysis of 801 articles, the results provide a retrospective and comprehensive visualized view of the research hotspots and frontiers of TAK1 at the crossroads of multiple RCD signaling pathways and propose ideas for guiding their future investigations in molecular mechanisms and therapeutic strategies in this field.

References

Lam C, Tan C, Teo Z, Tay C, Phua T, Wu Y . Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial-mesenchymal transition of cancer cells. Cell Death Dis. 2013; 4:e848. PMC: 3824649. DOI: 10.1038/cddis.2013.339. View

Ajibade A, Wang H, Wang R . Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol. 2013; 34(7):307-16. DOI: 10.1016/j.it.2013.03.007. View

Zhao W, Fan C, Hu X, Ban X, Wan H, He Y . Regulated Cell Death of Retinal Ganglion Cells in Glaucoma: Molecular Insights and Therapeutic Potentials. Cell Mol Neurobiol. 2023; 43(7):3161-3178. PMC: 11410022. DOI: 10.1007/s10571-023-01373-1. View

Li H, Kobayashi M, Blonska M, You Y, Lin X . Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem. 2006; 281(19):13636-13643. DOI: 10.1074/jbc.M600620200. View

Huang Y, Wang S, Huang F, Zhang Q, Qin B, Liao L . c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway. Ann Anat. 2021; 235:151672. DOI: 10.1016/j.aanat.2020.151672. View

Zhou X, Zhang L, Lie L, Zhang Z, Zhu B, Yang J . MxA suppresses TAK1-IKKα/β-NF-κB mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection. J Infect. 2020; 81(2):231-241. DOI: 10.1016/j.jinf.2020.05.030. View

Shim J, Xiao C, Paschal A, Bailey S, Rao P, Hayden M . TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005; 19(22):2668-81. PMC: 1283960. DOI: 10.1101/gad.1360605. View

Kanayama A, Seth R, Sun L, Ea C, Hong M, Shaito A . TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004; 15(4):535-48. DOI: 10.1016/j.molcel.2004.08.008. View

Yang F, He Y, Zhai Z, Sun E . Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus. J Immunol Res. 2019; 2019:3638562. PMC: 6913273. DOI: 10.1155/2019/3638562. View

10.

Wang Q, Zhou X, Zhao Y, Xiao J, Lu Y, Shi Q . Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway. Front Immunol. 2018; 9:2091. PMC: 6170622. DOI: 10.3389/fimmu.2018.02091. View

11.

Wree A, Eguchi A, McGeough M, Pena C, Johnson C, Canbay A . NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2013; 59(3):898-910. PMC: 4008151. DOI: 10.1002/hep.26592. View

12.

Weber A, Wasiliew P, Kracht M . Interleukin-1 (IL-1) pathway. Sci Signal. 2010; 3(105):cm1. DOI: 10.1126/scisignal.3105cm1. View

13.

Ikushima H, Miyazono K . TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer. 2010; 10(6):415-24. DOI: 10.1038/nrc2853. View

14.

Newton K, Wickliffe K, Dugger D, Maltzman A, Roose-Girma M, Dohse M . Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019; 574(7778):428-431. DOI: 10.1038/s41586-019-1548-x. View

15.

Mukhopadhyay H, Lee N . Multifaceted roles of TAK1 signaling in cancer. Oncogene. 2019; 39(7):1402-1413. PMC: 7023988. DOI: 10.1038/s41388-019-1088-8. View

16.

Chen X, Dai Y, Wan X, Hu X, Zhao W, Ban X . ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications. Molecules. 2023; 28(1). PMC: 9822119. DOI: 10.3390/molecules28010052. View

17.

Hamidi A, von Bulow V, Hamidi R, Winssinger N, Barluenga S, Heldin C . Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli. J Biol Chem. 2011; 287(1):123-133. PMC: 3249064. DOI: 10.1074/jbc.M111.285122. View

18.

Ouyang G, Li Q, Wei Y, Dai W, Deng H, Liu Y . Identification of PANoptosis-related subtypes, construction of a prognosis signature, and tumor microenvironment landscape of hepatocellular carcinoma using bioinformatic analysis and experimental verification. Front Immunol. 2024; 15:1323199. PMC: 11089137. DOI: 10.3389/fimmu.2024.1323199. View

19.

Wang L, Zhang X, Lin Z, Yang P, Xu H, Duan J . Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. Cell Metab. 2021; 33(7):1372-1388.e7. DOI: 10.1016/j.cmet.2021.05.019. View

20.

Zhou J, Zhong J, Huang Z, Liao M, Lin S, Chen J . TAK1 mediates apoptosis via p38 involve in ischemia-induced renal fibrosis. Artif Cells Nanomed Biotechnol. 2018; 46(sup1):1016-1025. DOI: 10.1080/21691401.2018.1442841. View