Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

Overview

Journal Environ Health (Wash)

Publisher American Chemical Society

Date 2024 Oct 30

PMID 39473887

Authors

Zhiming Li

Hongyi Xian

Xiaohu Ren

Rongyi Ye

Yizhou Zhong

Yuji Huang

Boxuan Liang

Yanhong Deng

Mingzhu Dai

Jie Guo

Shuqin Tang

Jialiang Pan

Yu Feng

Ruobing Bai

Xueping Chen

Sahoko Ichihara

Gaku Ichihara

Da Chen

Xingfen Yang

Zhenlie Huang

Affiliations

Soon will be listed here.

Abstract

Triclosan (TCS) has garnered significant attention due to its widespread use and associated endocrine-disrupting effects. However, its impact on the neuroendocrine system and underlying mechanisms remain poorly understood. Here, we established correlations between TCS exposure and serum sex hormone levels in participants of the National Health and Nutrition Examination Survey (NHANES). Additionally, we investigated TCS's influence on the neuroendocrine system using adult zebrafish exposed to environmentally relevant concentrations of TCS (0.361-48.2 μg/L) for 21 days. Assessment of reproductive and neurotoxicity included histopathological examination and behavioral tests. Transcriptomics, proteomics analyses, and biochemical detection were employed to elucidate mechanisms underlying TCS-induced neuroendocrine disruption. Significant correlations were found between TCS exposure and estradiol, testosterone, and sex hormone-binding globulin levels in NHANES participants. In addition, TCS exposure inhibited ovary development and spermatogenesis in zebrafish. Transcriptomics and proteomics analysis revealed gender-specific key signaling and metabolism-related pathways implicated in TCS-induced reproductive toxicity. Moreover, TCS exposure induced nervous system impairment, as evidenced by histological changes and altered motor behavior, possibly associated with oxidative damage. Correlation analysis further highlighted the potential connection between endocrine system disruption and nervous system impairment following TCS exposure. Overall, this study provided evidence supporting TCS-induced endocrine disruption and offered insights into its underlying mechanisms.

Citing Articles

Methylation Partially Mediated the Association of Exposure to Triclosan but Not Triclocarban with Type 2 Diabetes Mellitus: A Case-Control Study.

Gao Q, Huan C, Jia Z, Cao Q, Yuan P, Li X Int J Mol Sci. 2024; 25(22).

PMID: 39596180 PMC: 11594987. DOI: 10.3390/ijms252212113.

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