Identification of Exosomal CeRNA Networks As Prognostic Markers in Clear Cell Renal Cell Carcinoma

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2024 Oct 29

PMID 39470474

Authors

Tao Zhu

Haizhu Fu

Zhiqiang Wang

Shanchun Guo

Shidong Zhang

Affiliations

Soon will be listed here.

Abstract

Aggressive clear cell renal cell carcinoma (ccRCC) has a bad prognosis. We seek new ccRCC biomarkers for diagnosis and treatment. We used exoRBase and The Cancer Genome Atlas Database to compare DEmRNAs, DEmiRNAs, DElncRNAs, and DEcircRNAs in ccRCC and normal renal tissues. CircRNAs and circRNAs targeting microRNAs (miRNAs) were anticipated and taken intersections, and several databases assessed the targeted link between common miRNAs and messenger RNAs (mRNAs). The Cancer Genome Atlas database was used to create a predictive mRNA signature that was validated in E-MTAB-1980. Finally, we examined competing endogenous RNA network miRNAs and long noncoding RNAs for ccRCC predictive biomarkers using overall survival analysis. We built the first competing endogenous RNA regulation network of circRNA-lncRNA-miRNA-mRNA and found that it substantially correlates with ccRCC prognosis. We unveiled ccRCC's posttranscriptional regulation mechanism in greater detail. Our findings identified novel biomarkers for ccRCC diagnosis, therapy, and prognosis.

References

Gu Y, Niu S, Wang Y, Duan L, Pan Y, Tong Z . -Mediated Regulation of mA-Modified by mA Reader IGF2BP3 Drives ccRCC Progression. Cancer Res. 2020; 81(4):923-934. DOI: 10.1158/0008-5472.CAN-20-1619. View

Razavinia A, Razavinia A, Jamshidi Khalife Lou R, Ghavami M, Shahri F, Tafazoli A . Exosomes as novel tools for renal cell carcinoma therapy, diagnosis, and prognosis. Heliyon. 2024; 10(12):e32875. PMC: 11211897. DOI: 10.1016/j.heliyon.2024.e32875. View

Kaiser J . Malignant messengers. Science. 2016; 352(6282):164-6. DOI: 10.1126/science.352.6282.164. View

Yeung C, Co N, Tsuruga T, Yeung T, Kwan S, Leung C . Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1. Nat Commun. 2016; 7:11150. PMC: 4820618. DOI: 10.1038/ncomms11150. View

Xia S, Feng J, Chen K, Ma Y, Gong J, Cai F . CSCD: a database for cancer-specific circular RNAs. Nucleic Acids Res. 2017; 46(D1):D925-D929. PMC: 5753219. DOI: 10.1093/nar/gkx863. View

Horie K, Kawakami K, Fujita Y, Sugaya M, Kameyama K, Mizutani K . Exosomes expressing carbonic anhydrase 9 promote angiogenesis. Biochem Biophys Res Commun. 2017; 492(3):356-361. DOI: 10.1016/j.bbrc.2017.08.107. View

Naseer Q, Malik A, Zhang F, Chen S . Exploring the enigma: history, present, and future of long non-coding RNAs in cancer. Discov Oncol. 2024; 15(1):214. PMC: 11161455. DOI: 10.1007/s12672-024-01077-y. View

Zhu G, Pei L, Yin H, Lin F, Li X, Zhu X . Profiles of tumor-infiltrating immune cells in renal cell carcinoma and their clinical implications. Oncol Lett. 2019; 18(5):5235-5242. PMC: 6781756. DOI: 10.3892/ol.2019.10896. View

Hansen T, Jensen T, Clausen B, Bramsen J, Finsen B, Damgaard C . Natural RNA circles function as efficient microRNA sponges. Nature. 2013; 495(7441):384-8. DOI: 10.1038/nature11993. View

10.

Nail H, Chiu C, Leung C, Ahmed M, Wang H . Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments. J Biomed Sci. 2023; 30(1):69. PMC: 10440907. DOI: 10.1186/s12929-023-00964-w. View

11.

Liu H, Zhu Z, Fang J, Liu T, Zhang Z, Zhao C . The ceRNA Network Has Potential Prognostic Value in Clear Cell Renal Cell Carcinoma: A Study Based on TCGA Database. Biomed Res Int. 2020; 2020:4830847. PMC: 7335400. DOI: 10.1155/2020/4830847. View

12.

Glazar P, Papavasileiou P, Rajewsky N . circBase: a database for circular RNAs. RNA. 2014; 20(11):1666-70. PMC: 4201819. DOI: 10.1261/rna.043687.113. View

13.

Yang Y, Hong Y, Nam G, Chung J, Koh E, Kim I . Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes. Adv Mater. 2017; 29(13). DOI: 10.1002/adma.201605604. View

14.

Tay Y, Rinn J, Pandolfi P . The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014; 505(7483):344-52. PMC: 4113481. DOI: 10.1038/nature12986. View

15.

Milane L, Singh A, Mattheolabakis G, Suresh M, Amiji M . Exosome mediated communication within the tumor microenvironment. J Control Release. 2015; 219:278-294. DOI: 10.1016/j.jconrel.2015.06.029. View

16.

Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W . Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015; 527(7576):100-104. PMC: 4819404. DOI: 10.1038/nature15376. View

17.

Carbone M, Yang H, Pass H, Krausz T, Testa J, Gaudino G . BAP1 and cancer. Nat Rev Cancer. 2013; 13(3):153-9. PMC: 3792854. DOI: 10.1038/nrc3459. View

18.

Zhang S, Zhang E, Long J, Hu Z, Peng J, Liu L . Immune infiltration in renal cell carcinoma. Cancer Sci. 2019; 110(5):1564-1572. PMC: 6501001. DOI: 10.1111/cas.13996. View

19.

Zhang W, Ni M, Su Y, Wang H, Zhu S, Zhao A . MicroRNAs in Serum Exosomes as Potential Biomarkers in Clear-cell Renal Cell Carcinoma. Eur Urol Focus. 2017; 4(3):412-419. DOI: 10.1016/j.euf.2016.09.007. View

20.

Su L, Zhang Y, Wang Y, Wei H . Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer's Disease. J Integr Neurosci. 2024; 22(6):136. DOI: 10.31083/j.jin2206136. View