It Takes Two to Tango: Preserving Daptomycin Efficacy Against Daptomycin-resistant MRSA Using Daptomycin-phage Co-therapy

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2024 Oct 29

PMID 39470283

Authors

Casey L Madison

Anja S J Steinert

Corrin E Luedeke

Neeka Hajjafar

Prakhar Srivastava

Andrew D Berti

Arnold S Bayer

Razieh Kebriaei

Affiliations

Soon will be listed here.

Abstract

Importance: Multidrug-resistant is a threat to the health care system, especially cross-resistance between daptomycin (DAP) and glycopeptides through various mutations such as (which is involved in the modification of membrane phospholipids in some bacteria) and yycG (part of a two-component regulatory system in bacteria that is important for regulating cell wall biosynthesis and other cellular processes) has been reported previously. Our current study shows adjunctive treatment with phage in DAP-resistant strains will lead to synergistic activity and larger phage plaque sizes, translating to elevated lytic performance. The addition of bacteriophage to standard-of-care antibiotic therapies for multidrug-resistant infections has the potential to hinder, and possibly revert, resistance to antibiotics. Applying this strategy can potentially lead to the preservation of the current antibiotics. Verification of this salutary outcome in relevant and models of endovascular infections is required to validate translatability.

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