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Ex-Vivo TCR αβ and CD19 Depleted Haploidentical Stem Cell Transplantation with CD45RO Memory T Cell Addback for CARD11 Deficiency

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Specialty Hematology
Date 2024 Oct 29
PMID 39469150
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References
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Greil J, Rausch T, Giese T, Bandapalli O, Daniel V, Bekeredjian-Ding I . Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency. J Allergy Clin Immunol. 2013; 131(5):1376-83.e3. DOI: 10.1016/j.jaci.2013.02.012. View

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Fuchs S, Rensing-Ehl A, Pannicke U, Lorenz M, Fisch P, Jeelall Y . Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency. Blood. 2015; 126(14):1658-69. PMC: 4654427. DOI: 10.1182/blood-2015-03-631374. View

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Stepensky P, Keller B, Buchta M, Kienzler A, Elpeleg O, Somech R . Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects. J Allergy Clin Immunol. 2013; 131(2):477-85.e1. DOI: 10.1016/j.jaci.2012.11.050. View

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Dunaikina M, Zhekhovtsova Z, Shelikhova L, Glushkova S, Nikolaev R, Blagov S . Safety and efficacy of the low-dose memory (CD45RA-depleted) donor lymphocyte infusion in recipients of αβ T cell-depleted haploidentical grafts: results of a prospective randomized trial in high-risk childhood leukemia. Bone Marrow Transplant. 2021; 56(7):1614-1624. DOI: 10.1038/s41409-021-01232-x. View