Thyroid Function Tests in Healthy Kittens Aged Between 2 and 16 Weeks

Overview

Journal J Feline Med Surg

Specialty Veterinary Medicine

Date 2024 Oct 28

PMID 39466883

Authors

Christina L Marino

Timothy A Bolton

Margret L Casal

Affiliations

Soon will be listed here.

Abstract

Objectives: This study aimed to determine thyroid hormone concentrations in a cohort of healthy kittens due to the paucity of information in the literature, and the potential for congenital hypothyroidism (CH) to contribute to fading kitten syndrome (FKS).

Methods: The serum concentrations of total thyroxine (TT4), free thyroxine (fT4), total triiodothyronine (TT3), free triiodothyronine (fT3) and thyroid-stimulating hormone (TSH) were measured in 19 healthy kittens aged 2-16 weeks.

Results: Mean TT4, fT4, TT3 and fT3 concentrations significantly differed across age groups. Mean TT4 and fT4 concentrations peaked at 6 and 5 weeks of age, respectively. The TT4 concentration exceeded the adult cat reference interval (ACRI) in 54% (32/59) of samples at week 6, with the highest TT4 concentration being 7.1 µg/dl (91 nmol/l). Mean TT3 and fT3 concentrations also peaked at 6 weeks of age. Mean TT3 concentration started below the ACRI until 4 weeks of age, after which it remained within the ACRI. The mean fT3 concentration was within the ACRI at all ages. The mean TSH concentration did not differ across age groups and remained within the ACRI in nearly 100% of samples.

Conclusions And Relevance: Peak TT4, fT4, TT3 and fT3 concentrations in healthy kittens at 5 and 6 weeks of age are likely due to changes in the maternal transfer of thyroid hormones after weaning and organ system development. Knowing healthy neonatal and pediatric thyroid hormone concentrations in a cohort of kittens might help a veterinarian interpret thyroid hormone levels when trying to rule out CH in a kitten with FKS.

References

Geffre A, Friedrichs K, Harr K, Concordet D, Trumel C, Braun J . Reference values: a review. Vet Clin Pathol. 2009; 38(3):288-98. DOI: 10.1111/j.1939-165X.2009.00179.x. View

Peterson M . Primary goitrous hypothyroidism in a young adult domestic longhair cat: diagnosis and treatment monitoring. JFMS Open Rep. 2017; 1(2):2055116915615153. PMC: 5362015. DOI: 10.1177/2055116915615153. View

Golinelli S, Tardo A, Vecchiato C, Guido E, Perfetti S, Diana A . Evaluation of Weight Gain, Clinicopathological and Radiographic Changes after Early Diagnosis and Treatment of Congenital Hypothyroidism in Cats. Vet Sci. 2022; 9(3). PMC: 8950234. DOI: 10.3390/vetsci9030140. View

Refsal K, Nachreiner R, Stein B, Currigan C, Zendel A, Thacker E . Use of the triiodothyronine suppression test for diagnosis of hyperthyroidism in ill cats that have serum concentration of iodothyronines within normal range. J Am Vet Med Assoc. 1991; 199(11):1594-601. View

Peterson M, Guterl J, Nichols R, Rishniw M . Evaluation of Serum Thyroid-Stimulating Hormone Concentration as a Diagnostic Test for Hyperthyroidism in Cats. J Vet Intern Med. 2015; 29(5):1327-34. PMC: 4858046. DOI: 10.1111/jvim.13585. View

Uchiyama A, Watanabe H, Nakanishi H, Totsu S . Small for gestational age is a risk factor for the development of delayed thyrotropin elevation in infants weighing less than 2000 g. Clin Endocrinol (Oxf). 2018; 89(4):431-436. DOI: 10.1111/cen.13793. View

Akasha M, Anderson R, Ellersieck M, Nixon D . Concentration of thyroid hormones and prolactin in dairy cattle serum and milk at three stages of lactation. J Dairy Sci. 1987; 70(2):271-6. DOI: 10.3168/jds.S0022-0302(87)80007-3. View

Lee G, Park S, Park J, Kang S . Development of delayed thyroid stimulating hormone elevation in small-for-gestational-age infants: is a second screening needed?. Ann Pediatr Endocrinol Metab. 2022; 28(1):42-48. PMC: 10073029. DOI: 10.6065/apem.2244002.001. View

Clark S, Deming D, Emery J, Adams L, Carlton E, Nelson J . Reference ranges for thyroid function tests in premature infants beyond the first week of life. J Perinatol. 2002; 21(8):531-6. DOI: 10.1038/sj.jp.7210572. View

10.

Lavely J . Pediatric neurology of the dog and cat. Vet Clin North Am Small Anim Pract. 2006; 36(3):475-501, v. DOI: 10.1016/j.cvsm.2005.12.009. View

11.

Grundy S . Clinically relevant physiology of the neonate. Vet Clin North Am Small Anim Pract. 2006; 36(3):443-59, v. DOI: 10.1016/j.cvsm.2005.12.002. View

12.

Abend G, de Azevedo S, Dos Santos A, Cobucci G, de Souza H . Feline congenital hypothyroidism: a case report. Braz J Vet Med. 2023; 45:e003423. PMC: 10680995. DOI: 10.29374/2527-2179.bjvm003423. View

13.

Fisher D, Dussault J, Sack J, Chopra I . Ontogenesis of hypothalamic--pituitary--thyroid function and metabolism in man, sheep, and rat. Recent Prog Horm Res. 1976; 33:59-116. DOI: 10.1016/b978-0-12-571133-3.50010-6. View

14.

Munnich A . Fading kitten syndrome: Factors predisposing to 'faders' and treatment options. J Feline Med Surg. 2022; 24(3):243-256. PMC: 10845402. DOI: 10.1177/1098612X221079710. View

15.

Liu C, Wang K, Guo J, Chen J, Chen M, Xie Z . Small for gestational age is a risk factor for thyroid dysfunction in preterm newborns. BMC Pediatr. 2020; 20(1):179. PMC: 7178556. DOI: 10.1186/s12887-020-02089-7. View

16.

Lee J, Kim S, Jeon G, Sin J . Thyroid dysfunction in very low birth weight preterm infants. Korean J Pediatr. 2015; 58(6):224-9. PMC: 4510356. DOI: 10.3345/kjp.2015.58.6.224. View

17.

Ogilvy-Stuart A . Neonatal thyroid disorders. Arch Dis Child Fetal Neonatal Ed. 2002; 87(3):F165-71. PMC: 1721489. DOI: 10.1136/fn.87.3.f165. View

18.

Beleslin D, Samardzic R . Proceedings: Effect of thyroxine on the body temperature after its intraventricular injection into conscious cats. J Physiol. 1974; 238(1):27P-28P. View

19.

Mandel S, Hermos R, Larson C, Prigozhin A, ROJAS D, Mitchell M . Atypical hypothyroidism and the very low birthweight infant. Thyroid. 2000; 10(8):693-5. DOI: 10.1089/10507250050137770. View

20.

Somers K, Royals M, Carstea E, Rafi M, Wenger D, Thrall M . Mutation analysis of feline Niemann-Pick C1 disease. Mol Genet Metab. 2003; 79(2):99-103. DOI: 10.1016/s1096-7192(03)00074-x. View