Targeting the Circadian Modulation: Novel Therapeutic Approaches in the Management of ASD

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2024 Oct 28

PMID 39465045

Authors

Yuxing Zhang

Yinan Chen

Wu Li

Liya Tang

Jiangshan Li

Xiang Feng

Affiliations

Soon will be listed here.

Abstract

Circadian dysfunction is prevalent in neurodevelopmental disorders, particularly in autism spectrum disorder (ASD). A plethora of empirical studies demonstrate a strong correlation between ASD and circadian disruption, suggesting that modulation of circadian rhythms and the clocks could yield satisfactory advancements. Research indicates that circadian dysfunction associated with abnormal neurodevelopmental phenotypes in ASD individuals, potentially contribute to synapse plasticity disruption. Therefore, targeting circadian rhythms may emerge as a key therapeutic approach. In this study, we did a brief review of the mammalian circadian clock, and the correlation between the circadian mechanism and the pathology of ASD at multiple levels. In addition, we highlight that circadian is the target or modulator to participate in the therapeutic approaches in the management of ASD, such as phototherapy, melatonin, modulating circadian components, natural compounds, and chronotherapies. A deep understanding of the circadian clock's regulatory role in the neurodevelopmental phenotypes in ASD may inspire novel strategies for improving ASD treatment.

References

Wang G, Grone B, Colas D, Appelbaum L, Mourrain P . Synaptic plasticity in sleep: learning, homeostasis and disease. Trends Neurosci. 2011; 34(9):452-63. PMC: 3385863. DOI: 10.1016/j.tins.2011.07.005. View

Pagan C, Goubran-Botros H, Delorme R, Benabou M, Lemiere N, Murray K . Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders. Sci Rep. 2017; 7(1):2096. PMC: 5437096. DOI: 10.1038/s41598-017-02152-x. View

Liang L, Zeng T, Zhao Y, Lu R, Guo B, Xie R . Melatonin pretreatment alleviates the long-term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor-mediated Wnt signaling modulation. J Pineal Res. 2021; 71(4):e12771. PMC: 9285571. DOI: 10.1111/jpi.12771. View

Gao X, Wei Y, Sun H, Hao S, Ma M, Sun H . Role of Bmal1 in Type 2 Diabetes Mellitus-Related Glycolipid Metabolic Disorder and Neuropsychiatric Injury: Involved in the Regulation of Synaptic Plasticity and Circadian Rhythms. Mol Neurobiol. 2023; 60(8):4595-4617. DOI: 10.1007/s12035-023-03360-5. View

Lorsung E, Karthikeyan R, Cao R . Biological Timing and Neurodevelopmental Disorders: A Role for Circadian Dysfunction in Autism Spectrum Disorders. Front Neurosci. 2021; 15:642745. PMC: 7994532. DOI: 10.3389/fnins.2021.642745. View

Eide E, Woolf M, Kang H, Woolf P, Hurst W, Camacho F . Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol. 2005; 25(7):2795-807. PMC: 1061645. DOI: 10.1128/MCB.25.7.2795-2807.2005. View

Proserpio P, Biggio G, Ferri R, Girardi P, Agostoni E, Manni R . Insomnia in primary care: a survey conducted on Italian patients older than 50 years-results from the "Sonno e Salute" study. Neurol Sci. 2022; 43(11):6487-6494. PMC: 9362688. DOI: 10.1007/s10072-022-06309-z. View

Hanada Y, Kawamura H . Circadian rhythms in synaptic excitability of the dorsal lateral geniculate nucleus in the rat. Int J Neurosci. 1984; 22(3-4):253-61. DOI: 10.3109/00207458408990682. View

Zhong H, Xiao R, Ruan R, Liu H, Li X, Cai Y . Neonatal curcumin treatment restores hippocampal neurogenesis and improves autism-related behaviors in a mouse model of autism. Psychopharmacology (Berl). 2020; 237(12):3539-3552. DOI: 10.1007/s00213-020-05634-5. View

10.

Bruning F, Noya S, Bange T, Koutsouli S, Rudolph J, Tyagarajan S . Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. 2019; 366(6462). DOI: 10.1126/science.aav3617. View

11.

Shapiro-Reznik M, Jilg A, Lerner H, Earnest D, Zisapel N . Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock. PLoS One. 2012; 7(5):e37894. PMC: 3360661. DOI: 10.1371/journal.pone.0037894. View

12.

Yenen A, Cak H . Melatonin and Circadian Rhythm in Autism Spectrum Disorders. Turk Psikiyatri Derg. 2020; 31(3):201-211. DOI: 10.5080/u25160. View

13.

Tordjman S, Davlantis K, Georgieff N, Geoffray M, Speranza M, Anderson G . Autism as a disorder of biological and behavioral rhythms: toward new therapeutic perspectives. Front Pediatr. 2015; 3:1. PMC: 4337381. DOI: 10.3389/fped.2015.00001. View

14.

Jasinska M, Jasek-Gajda E, Woznicka O, Lis G, Pyza E, Litwin J . Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex. PLoS One. 2019; 14(11):e0225394. PMC: 6857954. DOI: 10.1371/journal.pone.0225394. View

15.

Rivera-Bermudez M, Masana M, Brown G, Earnest D, Dubocovich M . Immortalized cells from the rat suprachiasmatic nucleus express functional melatonin receptors. Brain Res. 2004; 1002(1-2):21-7. DOI: 10.1016/j.brainres.2003.12.008. View

16.

Jayaprakash P, Isaev D, Shabbir W, Lorke D, Sadek B, Oz M . Curcumin Potentiates α7 Nicotinic Acetylcholine Receptors and Alleviates Autistic-Like Social Deficits and Brain Oxidative Stress Status in Mice. Int J Mol Sci. 2021; 22(14). PMC: 8303708. DOI: 10.3390/ijms22147251. View

17.

Malow B, Adkins K, McGrew S, Wang L, Goldman S, Fawkes D . Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. J Autism Dev Disord. 2011; 42(8):1729-37. PMC: 3368078. DOI: 10.1007/s10803-011-1418-3. View

18.

Garcia J, Zhang D, Estill S, Michnoff C, Rutter J, Reick M . Impaired cued and contextual memory in NPAS2-deficient mice. Science. 2000; 288(5474):2226-30. DOI: 10.1126/science.288.5474.2226. View

19.

HUTTENLOCHER P, Dabholkar A . Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol. 1997; 387(2):167-78. DOI: 10.1002/(sici)1096-9861(19971020)387:2<167::aid-cne1>3.0.co;2-z. View

20.

Roby D, Ruiz F, Kermath B, Voorhees J, Niehoff M, Zhang J . Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease. PLoS One. 2019; 14(4):e0215004. PMC: 6459530. DOI: 10.1371/journal.pone.0215004. View