Further Insights into The Pathogenic Mechanisms of Haemotropic

Overview

Journal Trop Life Sci Res

Date 2024 Oct 28

PMID 39464669

Authors

Paul Bura Thlama

Jesse Faez Firdaus Abdullah

Kamaludeen Juriah

Chung Eric Lim Teik

CheAmat Azlan

Mohd Lila Mohd Azmi

Affiliations

Soon will be listed here.

Abstract

In this study, we examined the effects of experimental intraperitoneal infection with haemotropic (0.5 mL of blood containing 80% parasitaemia) on selected serum biomarkers and cellular pathology in mice. After infection, cells appeared in the blood films within one week. A dose-dependent peak of parasitemia was observed during the 3-week post-infection (pi), with a significant decrease in mean PCV between treatment versus control group at week 3 ( = -3.693, 0.02), week 5 ( = -2.096, = 0.055), and week 7 ( = -4.329, 0.001). There was a significantly ( = -2.330, = 0.048) lower serum oestrogen in treatment (10.38 ± 5.07) than control (17.43 ± 4.48), while serum progesterone was significantly ( = 5.415, = 0.001) increased in treatment (27.37 ± 2.17) than control (15.92 ± 4.20). Serum haptoglobin was significantly ( = 8.525, < 0.01) lower in treatment (8.72 ± 1.49) than control (18.16 ± 1.98) while the SAA was significantly ( = 3.362, = 0.01) higher in treatment (16.79 ± 2.71) than control (11.59 ± 2.15). Prominent lesions observed in the ovary include degeneration, necrosis, vacuolation, and hypertrophy of the lutein cells in corpora lutea. In the lymph nodes, diffused cellular hyperplasia of the lymphoid tissue in the cortex. In the liver, degeneration and necrosis accompanied by leucocytic cellular infiltration and Kupffer cell proliferation within the sinusoids. There were diffused leucocytic infiltrations and proliferative lesions in the glomerulus of the kidneys. The disturbance in progesterone and ovarian pathology highlights the potential role of haemotropic in reproductive disorders. The observed changes in biomarkers and cellular reactions following infection in the mouse may be further advanced in sheep and goats.

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