The Relationship Between Advanced Lung Cancer Inflammation Index and High SYNTAX Score in Patients with Non-ST-elevation Myocardial Infarction

Overview

Journal Postepy Kardiol Interwencyjnej

Publisher Termedia

Specialty Cardiology & Vascular Diseases

Date 2024 Oct 28

PMID 39464597

Authors

Ali Hakan Konus

Ahmet Ozderya

Omer Faruk Cirakoglu

Muhammet Rasit Sayin

Murat Gokhan Yerlikaya

Affiliations

Soon will be listed here.

Abstract

Introduction: The advanced lung cancer inflammation index (ALI) is an independent prognostic biomarker of inflammation and nutrition in various types of cancer, acute heart failure and acute coronary syndrome. The SYNTAX (Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery) score (SXscore) is an angiographic scoring tool used to determine the extent and severity of coronary artery disease.

Aim: To investigate the relationship between ALI and coronary artery lesion complexity assessed using the SXscore in patients with non-ST-segment elevation myocardial infarction (NSTEMI).

Material And Methods: Between February and November 2020, a total of 284 patients with NSTEMI were included consecutively. ALI was calculated with the formula body mass index (BMI) × serum albumin concentration/neutrophil-to-lymphocyte ratio (NLR). SXscore was calculated using the online calculator and divided into two groups - low (< 32) and high (≥ 33) - and then analyzed.

Results: Patients with a high SXscore had lower ALI (22.4 ±7.3 vs. 58.5 ±44.3, = 0.016). In the univariable analysis, age ( = 0.046), BMI ( = 0.021), C-reactive protein ( = 0.002), peak troponin I ( = 0.009), NLR ( = 0.025), serum albumin ( = 0.003) and ALI ( < 0.001) were significantly associated with a high SXscore. ALI emerged as an independent predictor of a high SXscore in multivariable analysis (95% CI: 0.931-0.984, = 0.002).

Conclusions: The ALI may be useful as a simple tool for predicting high SXscore in patients with NSTEMI. To our knowledge, this is the first study to examine the relationship between ALI and severity of CAD.

References

Ozderya A, Tekbil M, Erturk N, Maz M, Yerlikaya M, Sayin M . Comparison of coronary artery lesion complexity and body component parameters measured by TANITA. Postepy Kardiol Interwencyjnej. 2024; 20(1):37-44. PMC: 11008519. DOI: 10.5114/aic.2024.136905. View

Tamhane U, Aneja S, Montgomery D, Rogers E, Eagle K, Gurm H . Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008; 102(6):653-7. DOI: 10.1016/j.amjcard.2008.05.006. View

Tomita M, Ayabe T, Nakamura K . The advanced lung cancer inflammation index is an independent prognostic factor after surgical resection in patients with non-small-cell lung cancer. Interact Cardiovasc Thorac Surg. 2017; 26(2):288-292. DOI: 10.1093/icvts/ivx329. View

Guasti L, Dentali F, Castiglioni L, Maroni L, Marino F, Squizzato A . Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. A systematic review on more than 34,000 subjects. Thromb Haemost. 2011; 106(4):591-9. DOI: 10.1160/TH11-02-0096. View

Montecucco F, Liberale L, Bonaventura A, Vecchie A, Dallegri F, Carbone F . The Role of Inflammation in Cardiovascular Outcome. Curr Atheroscler Rep. 2017; 19(3):11. DOI: 10.1007/s11883-017-0646-1. View

Magro M, Nauta S, Simsek C, Boersma E, van der Heide E, Regar E . Usefulness of the SYNTAX score to predict "no reflow" in patients treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Am J Cardiol. 2011; 109(5):601-6. DOI: 10.1016/j.amjcard.2011.10.013. View

Uthamalingam S, Patvardhan E, Subramanian S, Ahmed W, Martin W, Daley M . Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011; 107(3):433-8. DOI: 10.1016/j.amjcard.2010.09.039. View

Park Y, Yi H, Lee M, Kim C, Lim J . Prognostic Value of the Pretreatment Advanced Lung Cancer Inflammation Index (ALI) in Diffuse Large B Cell Lymphoma Patients Treated with R-CHOP Chemotherapy. Acta Haematol. 2017; 137(2):76-85. DOI: 10.1159/000452991. View

Rubinshtein R, Halon D, Jaffe R, Shahla J, Lewis B . Relation between obesity and severity of coronary artery disease in patients undergoing coronary angiography. Am J Cardiol. 2006; 97(9):1277-80. DOI: 10.1016/j.amjcard.2005.11.061. View

10.

Doring Y, Drechsler M, Soehnlein O, Weber C . Neutrophils in atherosclerosis: from mice to man. Arterioscler Thromb Vasc Biol. 2014; 35(2):288-95. DOI: 10.1161/ATVBAHA.114.303564. View

11.

Parsa A, Jahanshahi B . Is the relationship of body mass index to severity of coronary artery disease different from that of waist-to-hip ratio and severity of coronary artery disease? Paradoxical findings. Cardiovasc J Afr. 2015; 26(1):13-6. PMC: 4814759. DOI: 10.5830/CVJA-2014-054. View

12.

Fioranelli M, Bottaccioli A, Bottaccioli F, Bianchi M, Rovesti M, Roccia M . Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based. Front Immunol. 2018; 9:2031. PMC: 6135895. DOI: 10.3389/fimmu.2018.02031. View

13.

Capodanno D, Capranzano P, Di Salvo M, Caggegi A, Tomasello D, Cincotta G . Usefulness of SYNTAX score to select patients with left main coronary artery disease to be treated with coronary artery bypass graft. JACC Cardiovasc Interv. 2009; 2(8):731-8. DOI: 10.1016/j.jcin.2009.06.003. View

14.

Ridker P . Residual inflammatory risk: addressing the obverse side of the atherosclerosis prevention coin. Eur Heart J. 2016; 37(22):1720-2. DOI: 10.1093/eurheartj/ehw024. View

15.

Jank B, Kadletz L, Schnoll J, Selzer E, Perisanidis C, Heiduschka G . Prognostic value of advanced lung cancer inflammation index in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2019; 276(5):1487-1492. DOI: 10.1007/s00405-019-05381-0. View

16.

Wang X, Wei C, Fan W, Sun L, Zhang Y, Sun Q . Advanced Lung Cancer Inflammation Index for Predicting Prognostic Risk for Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. J Inflamm Res. 2023; 16:3631-3641. PMC: 10460579. DOI: 10.2147/JIR.S421021. View

17.

Libby P . Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012; 32(9):2045-51. PMC: 3422754. DOI: 10.1161/ATVBAHA.108.179705. View

18.

Levey A, Bosch J, Lewis J, Greene T, Rogers N, Roth D . A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999; 130(6):461-70. DOI: 10.7326/0003-4819-130-6-199903160-00002. View

19.

KRAUSS , Winston , Fletcher , Grundy . Obesity : impact on cardiovascular disease . Circulation. 1998; 98(14):1472-6. View

20.

Sakai H, Tsutamoto T, Ishikawa C, Tanaka T, Fujii M, Yamamoto T . Direct comparison of brain natriuretic peptide (BNP) and N-terminal pro-BNP secretion and extent of coronary artery stenosis in patients with stable coronary artery disease. Circ J. 2007; 71(4):499-505. DOI: 10.1253/circj.71.499. View