Lymphoepithelial Carcinoma of the Lung: A Case Report and Review of the Literature

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Oct 28

PMID 39463559

Authors

Menelaos G Samaras

Nektarios I Koufopoulos

Sofoklis Mitsos

Eris Dylja

Athanasia Monokrousou

Periklis Tomos

Ioannis G Panayiotides

Dimitrios Goutas

Affiliations

Soon will be listed here.

Abstract

Lymphoepithelial or lymphoepithelioma-like carcinoma is a poorly differentiated carcinoma located outside the nasopharynx with similar morphologic characteristics to its nasopharyngeal counterpart. Lymphoepithelial carcinoma of the lung is a rare subtype of squamous cell lung carcinoma frequently associated with Epstein-Barr virus (EBV) infection, accounting for approximately 1% of non-small cell lung carcinomas (NSCLC). We herewith present a case of a 78-year-old female patient who was diagnosed with lymphoepithelial carcinoma of the lung, emphasizing its distinct epidemiological features, clinical workup, and histopathological characteristics. Furthermore, we discuss its histologic differential diagnosis. Finally, we refer to this tumor's unique molecular and immunological profile and its treatment modalities, and we review the literature.

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