The Impact of Neonicotinoid Pesticides on Reproductive health

Overview

Journal Toxicol Sci

Publisher Oxford University Press

Specialty Toxicology

Date 2024 Oct 26

PMID 39460954

Authors

Jadesola I Oladosu

Jodi A Flaws

Affiliations

Soon will be listed here.

Abstract

Neonicotinoids are some of the most widely used insecticides in the world because they broadly target chewing and sucking insects. Neonicotinoids are used in commercial agricultural systems, sold for use in home gardens, and found in veterinary pharmaceuticals in the form of flea and tick preventatives for companion animals. They are also used as crop seed treatments and spread throughout crops as they mature. As a result, humans, wildlife, livestock, and pets are routinely exposed to neonicotinoids through the consumption of contaminated food and water as well as through the use of some veterinary pharmaceuticals. Although several studies indicate that neonicotinoid exposure causes genotoxicity, neurotoxicity, hepatotoxicity, and immunotoxicity in some non-target species, the impact of neonicotinoid pesticides on the male and female reproductive systems in mammals is largely understudied. This review summarizes current insights on the impact of common neonicotinoid pesticides such as acetamiprid, clothianidin, imidacloprid, and thiacloprid on male and female reproductive health in mammals. The review also summarizes the impacts of exposure to mixtures of neonicotinoids on reproductive endpoints. In addition, this review highlights where gaps in research on neonicotinoid pesticides and reproductive health exist so that future studies can be designed to fill current gaps in knowledge.

References

Mourikes V, Santacruz Marquez R, Deviney A, Neff A, Laws M, Flaws J . Imidacloprid and Its Bioactive Metabolite, Desnitro-Imidacloprid, Differentially Affect Ovarian Antral Follicle Growth, Morphology, and Hormone Synthesis In Vitro. Toxics. 2023; 11(4). PMC: 10141062. DOI: 10.3390/toxics11040349. View

Hernandez-Jerez A, Coja T, Paparella M, Price A, Henri J, Focks A . Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites. EFSA J. 2024; 22(5):e8759. PMC: 11094581. DOI: 10.2903/j.efsa.2024.8759. View

Paules C, Dantas A, Miranda J, Crovetto F, Eixarch E, Rodriguez-Sureda V . Premature placental aging in term small-for-gestational-age and growth-restricted fetuses. Ultrasound Obstet Gynecol. 2018; 53(5):615-622. DOI: 10.1002/uog.20103. View

Li Y, Wang H, Liu J, Li N, Wang Y, Wang W . Characterization of Prohibitins in Male Reproductive System and their Expression under Oxidative Stress. J Urol. 2015; 195(4 Pt 1):1160-7. DOI: 10.1016/j.juro.2015.10.179. View

Wang A, Wan Y, Zhou L, Xia W, Guo Y, Mahai G . Neonicotinoid insecticide metabolites in seminal plasma: Associations with semen quality. Sci Total Environ. 2021; 811:151407. DOI: 10.1016/j.scitotenv.2021.151407. View

Pan D, Lin M, Mu C, Yu C, Ye B, Liang J . Maternal exposure to neonicotinoid insecticides and fetal growth restriction: A nested case-control study in the guangxi Zhuang birth cohort. Chemosphere. 2023; 336:139217. DOI: 10.1016/j.chemosphere.2023.139217. View

Yue M, Liu Q, Wang F, Zhou W, Liu L, Wang L . Urinary neonicotinoid concentrations and pubertal development in Chinese adolescents: A cross-sectional study. Environ Int. 2022; 163:107186. DOI: 10.1016/j.envint.2022.107186. View

Suh J, Choi H, Kwon A, Chae H, Kim H . Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study. Clin Exp Pediatr. 2020; 63(4):146-150. PMC: 7170788. DOI: 10.3345/cep.2019.00416. View

Syeda S, Sanchez G, McDermott J, Hong K, Blanco G, Georg G . The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception†. Biol Reprod. 2020; 103(2):343-356. PMC: 7401355. DOI: 10.1093/biolre/ioaa093. View

10.

Kitauchi S, Maeda M, Hirano T, Ikenaka Y, Nishi M, Shoda A . Effects of in utero and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice. J Vet Med Sci. 2021; 83(4):746-753. PMC: 8111362. DOI: 10.1292/jvms.21-0014. View

11.

Chen D, Zhang Y, Lv B, Liu Z, Han J, Li J . Dietary exposure to neonicotinoid insecticides and health risks in the Chinese general population through two consecutive total diet studies. Environ Int. 2019; 135:105399. DOI: 10.1016/j.envint.2019.105399. View

12.

Wang X, Anadon A, Wu Q, Qiao F, Ares I, Martinez-Larranaga M . Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism. Annu Rev Pharmacol Toxicol. 2017; 58:471-507. DOI: 10.1146/annurev-pharmtox-010617-052429. View

13.

Hassanzadeh R, Joursaraei G, Hejazian L, Feazi F, Najafzadehvarzi H . Evaluation of the protective effect of melatonin on oocyte, embryo and ovarian tissue parameters in female mice exposed to acetamiprid. JBRA Assist Reprod. 2023; 27(3):407-413. PMC: 10712808. DOI: 10.5935/1518-0557.20220068. View

14.

Moenter S, Evans N . Gonadotropin-releasing hormone (GnRH) measurements in pituitary portal blood: A history. J Neuroendocrinol. 2021; 34(5):e13065. PMC: 9200367. DOI: 10.1111/jne.13065. View

15.

Bodereau-Dubois B, List O, Calas-List D, Marques O, Communal P, Thany S . Transmembrane potential polarization, calcium influx, and receptor conformational state modulate the sensitivity of the imidacloprid-insensitive neuronal insect nicotinic acetylcholine receptor to neonicotinoid insecticides. J Pharmacol Exp Ther. 2012; 341(2):326-39. DOI: 10.1124/jpet.111.188060. View

16.

Krishna R, Vishnu Bhat B . Molecular mechanisms of intrauterine growth restriction. J Matern Fetal Neonatal Med. 2017; 31(19):2634-2640. DOI: 10.1080/14767058.2017.1347922. View

17.

Matsuda K, Ihara M, Sattelle D . Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity. Annu Rev Pharmacol Toxicol. 2020; 60:241-255. DOI: 10.1146/annurev-pharmtox-010818-021747. View

18.

Cartereau A, Taillebois E, Le Questel J, Thany S . Mode of Action of Neonicotinoid Insecticides Imidacloprid and Thiacloprid to the Cockroach Pameα7 Nicotinic Acetylcholine Receptor. Int J Mol Sci. 2021; 22(18). PMC: 8471617. DOI: 10.3390/ijms22189880. View

19.

Wakabayashi H . [Basic studies on the "rebound phenomenon" of ovarian function]. Kita Kanto Igaku. 1962; 12:22-40. View

20.

Calas-List D, List O, Quinchard S, Thany S . Calcium pathways such as cAMP modulate clothianidin action through activation of α-bungarotoxin-sensitive and -insensitive nicotinic acetylcholine receptors. Neurotoxicology. 2013; 37:127-33. DOI: 10.1016/j.neuro.2013.04.011. View