Monocyte and Macrophage Functions in Oncogenic Viral Infections

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2024 Oct 26

PMID 39459945

Authors

Juliana Echevarria-Lima

Ramona Moles

Affiliations

Soon will be listed here.

Abstract

Monocytes and macrophages are part of innate immunity and constitute the first line of defense against pathogens. Bone marrow-derived monocytes circulate in the bloodstream for one to three days and then typically migrate into tissues, where they differentiate into macrophages. Circulatory monocytes represent 5% of the nucleated cells in normal adult blood. Following differentiation, macrophages are distributed into various tissues and organs to take residence and maintain body homeostasis. Emerging evidence has highlighted the critical role of monocytes/macrophages in oncogenic viral infections, mainly their crucial functions in viral persistence and disease progression. These findings open opportunities to target innate immunity in the context of oncogenic viruses and to explore their potential as immunotherapies.

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