Research Progress into the Biological Functions of IFITM3

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2024 Oct 26

PMID 39459876

Authors

Qian Xie

Liangliang Wang

Xinzhong Liao

Bi Huang

Chuming Luo

Guancheng Liao

Lifang Yuan

Xuejie Liu

Huanle Luo

Yuelong Shu

Affiliations

Soon will be listed here.

Abstract

Interferon-induced transmembrane proteins (IFITMs) are upregulated by interferons. They are not only highly conserved in evolution but also structurally consistent and have almost identical structural domains and functional domains. They are all transmembrane proteins and have multiple heritable variations in genes. The IFITM protein family is closely related to a variety of biological functions, including antiviral immunity, tumor formation, bone metabolism, cell adhesion, differentiation, and intracellular signal transduction. The progress of the research on its structure and related functions, as represented by IFITM3, is reviewed.

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