Nutritional Value of Oregano-Based Products and Its Effect on Rabbit Performance and Health

Overview

Journal Animals (Basel)

Date 2024 Oct 26

PMID 39457951

Authors

Ayman Abd El-Aziz

Ahmed Elfadadny

Mahmoud Abo Ghanima

Damiano Cavallini

Isa Fusaro

Melania Giammarco

Giovanni Buonaiuto

Karim El-Sabrout

Affiliations

Soon will be listed here.

Abstract

Antimicrobials long been used to enhance the performance and immunity of rabbits, typically by adding them to feed or drinking water to prevent illness. However, increasing consumer concerns about antibiotic-resistant microorganisms have led to a shift toward natural, eco-friendly, non-antibiotic feed supplements that can improve rabbit health and productivity. Recently, aromatic herbs and their extracts have gained considerable attention as natural antioxidants with growth-promoting and health-boosting properties. Essential oils and secondary metabolites play a central role in these effects, with (oregano) emerging as a standout option. Compared to synthetic alternatives, oregano is a natural, residue-free feed supplement with fewer harmful side effects. Its key bioactive components, thymol and carvacrol, have been shown to deliver significant benefits when incorporated into rabbit diets, particularly in improving production performance, immunity, and antioxidant capacity. Supplementing rabbit diets and drinking water with oregano essential oil (OEO) has been found to enhance growth performance, feed efficiency, and meat quality, while also lowering cholesterol levels and boosting antioxidant activity. Despite these promising results, research on the use of oregano in rabbit farming remains limited. This review aims to provide an up-to-date overview of the potential effect of oregano supplements, on growth parameters, carcass and meat quality, hemato-biochemical parameters, antioxidant capacity, immunity response, gut health, and gene expression in rabbits.

References

Llana-Ruiz-Cabello M, Maisanaba S, Puerto M, Pichardo S, Jos A, Moyano R . A subchronic 90-day oral toxicity study of Origanum vulgare essential oil in rats. Food Chem Toxicol. 2017; 101:36-47. DOI: 10.1016/j.fct.2017.01.001. View

Crowell P . Prevention and therapy of cancer by dietary monoterpenes. J Nutr. 1999; 129(3):775S-778S. DOI: 10.1093/jn/129.3.775S. View

Melillo A . Rabbit Clinical Pathology. J Exot Pet Med. 2020; 16(3):135-145. PMC: 7185592. DOI: 10.1053/j.jepm.2007.06.002. View

Abd El-Aziz A, Abo Ghanima M, Alsanie W, Gaber A, Alsenosy A, Easa A . Fructooligosaccharide Supplementation Boosts Growth Performance, Antioxidant Status, and Cecal Microbiota Differently in Two Rabbit Breeds. Animals (Basel). 2022; 12(12). PMC: 9219445. DOI: 10.3390/ani12121528. View

Serrano-Jara D, Rivera-Gomis J, Tornel J, Jordan M, Martinez-Conesa C, Pablo M . Oregano Essential Oil and Purple Garlic Powder Effects on Intestinal Health, Microbiota Indicators and Antimicrobial Resistance as Feed Additives in Weaning Piglets. Animals (Basel). 2024; 14(1). PMC: 10778277. DOI: 10.3390/ani14010111. View

Shehata A, Yalcin S, Latorre J, Basiouni S, Attia Y, Abd El-Wahab A . Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry. Microorganisms. 2022; 10(2). PMC: 8877156. DOI: 10.3390/microorganisms10020395. View

Liu L, Zhao X, Liu Y, Zhao H, Li F . Dietary addition of garlic straw improved the intestinal barrier in rabbits1. J Anim Sci. 2019; 97(10):4248-4255. PMC: 6776312. DOI: 10.1093/jas/skz277. View

Soares N, Bastos T, Kaelle G, de Souza R, de Oliveira S, Felix A . Digestibility and Palatability of the Diet and Intestinal Functionality of Dogs Fed a Blend of Yeast Cell Wall and Oregano Essential Oil. Animals (Basel). 2023; 13(15). PMC: 10416873. DOI: 10.3390/ani13152527. View

Rodriguez-Garcia I, Silva-Espinoza B, Ortega-Ramirez L, Leyva J, Siddiqui M, Cruz-Valenzuela M . Oregano Essential Oil as an Antimicrobial and Antioxidant Additive in Food Products. Crit Rev Food Sci Nutr. 2015; 56(10):1717-27. DOI: 10.1080/10408398.2013.800832. View

10.

Kim H, Kim H, Yun Y, Kang H . Effect of and Oregano Oil on Performance, Gut Microbiome, and Intestinal Morphology in Pullets. Animals (Basel). 2023; 13(16). PMC: 10451296. DOI: 10.3390/ani13162550. View

11.

Cui H, Zhang C, Su K, Fan T, Chen L, Yang Z . Oregano Essential Oil in Livestock and Veterinary Medicine. Animals (Basel). 2024; 14(11). PMC: 11171306. DOI: 10.3390/ani14111532. View

12.

Abd El-Aziz A, Abo Ghanima M, Mota-Rojas D, Sherasiya A, Ciani F, El-Sabrout K . Bee Products for Poultry and Rabbits: Current Challenges and Perspectives. Animals (Basel). 2023; 13(22). PMC: 10668745. DOI: 10.3390/ani13223517. View

13.

van der Sluis M, van Zeeland Y, de Greef K . Digestive problems in rabbit production: moving in the wrong direction?. Front Vet Sci. 2024; 11:1354651. PMC: 10879550. DOI: 10.3389/fvets.2024.1354651. View

14.

Napoli E, Siracusa L, Ruberto G . New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family. Chem Biodivers. 2020; 17(3):e1900677. DOI: 10.1002/cbdv.201900677. View

15.

Giorgino A, Raspa F, Valle E, Bergero D, Cavallini D, Gariglio M . Effect of Dietary Organic Acids and Botanicals on Metabolic Status and Milk Parameters in Mid-Late Lactating Goats. Animals (Basel). 2023; 13(5). PMC: 10000138. DOI: 10.3390/ani13050797. View

16.

El-Sabrout K, Sherasiya A, Ahmad S, Aggag S, Nannoni E, Cavallini D . Environmental Enrichment in Rabbit Husbandry: Comparative Impacts on Performance and Welfare. Animals (Basel). 2024; 14(16). PMC: 11350770. DOI: 10.3390/ani14162367. View

17.

Visan A, Negut I . Coatings Based on Essential Oils for Combating Antibiotic Resistance. Antibiotics (Basel). 2024; 13(7). PMC: 11273621. DOI: 10.3390/antibiotics13070625. View

18.

Botsoglou N, Florou-Paneri P, Christaki E, Fletouris D, Spais A . Effect of dietary oregano essential oil on performance of chickens and on iron-induced lipid oxidation of breast, thigh and abdominal fat tissues. Br Poult Sci. 2002; 43(2):223-30. DOI: 10.1080/00071660120121436. View

19.

Abdel-Wareth A, Taha E, Sudekum K, Lohakare J . Thyme oil inclusion levels in a rabbit ration: Evaluation of productive performance, carcass criteria and meat quality under hot environmental conditions. Anim Nutr. 2018; 4(4):410-416. PMC: 6284221. DOI: 10.1016/j.aninu.2018.02.004. View

20.

Soultos N, Tzikas Z, Christaki E, Papageorgiou K, Steris V . The effect of dietary oregano essential oil on microbial growth of rabbit carcasses during refrigerated storage. Meat Sci. 2010; 81(3):474-8. DOI: 10.1016/j.meatsci.2008.10.001. View