Evaluation of Selenium Concentrations in Patients with Crohn's Disease and Ulcerative Colitis

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2024 Oct 26

PMID 39457481

Authors

Michal Chalcarz

Beniamin Oskar Grabarek

Tomasz Sirek

Agata Sirek

Piotr Ossowski

Mateusz Wilk

Katarzyna Krol-Jatrega

Konrad Dziobek

Julia Gajdeczka

Jaroslaw Madowicz

Damian Strojny

Kacper Boron

Jakub Zurawski

Affiliations

Soon will be listed here.

Abstract

Background/objectives: In this study, serum selenium levels in patients with Crohn's disease (CD) and ulcerative colitis (UC) were evaluated to identify potential predictive markers of disease activity. Conducted in 100 inflammatory bowel disease (IBD) patients (54 CD, 46 UC) and 100 healthy controls, this research provides novel insights through focusing on the regional selenium status of people with IBD in the Polish population, a demographic with limited existing data.

Methods: Selenium concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS).

Results: Significantly lower levels of selenium were observed in CD (64.79 µg/L ± 12.15 µg/L) and UC (68.61 µg/L ± 11.43 µg/L) patients when compared with the controls (90.52 ± 12.00 µg/L, < 0.0001). Regression analysis identified leukocyte and erythrocyte counts and bilirubin as significant predictors of selenium levels in UC patients, while no significant predictors were found for CD.

Conclusions: The findings suggest that selenium deficiency is linked to IBD and may serve as a non-invasive biomarker for disease severity, particularly in UC. This practical approach offers a potential alternative to invasive procedures such as endoscopy for monitoring disease progression. However, further research is needed to confirm these findings in larger populations and explore the therapeutic role of selenium supplementation in IBD management.

References

McNeill R, Barclay M . Cost-effectiveness of therapeutic drug monitoring in inflammatory bowel disease. Curr Opin Pharmacol. 2020; 55:41-46. DOI: 10.1016/j.coph.2020.09.006. View

Segal J, LeBlanc J, Hart A . Ulcerative colitis: an update. Clin Med (Lond). 2021; 21(2):135-139. PMC: 8002778. DOI: 10.7861/clinmed.2021-0080. View

Bourgonje A, von Martels J, Gabriels R, Blokzijl T, Buist-Homan M, Heegsma J . A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease. Front Med (Lausanne). 2019; 6:251. PMC: 6849495. DOI: 10.3389/fmed.2019.00251. View

Khattab A, Darwish A, Othman S, Allam A, Alqhtani H . Anti-inflammatory and Immunomodulatory Potency of Selenium-Enriched Probiotic Mutants in Mice with Induced Ulcerative Colitis. Biol Trace Elem Res. 2022; 201(1):353-367. PMC: 9823042. DOI: 10.1007/s12011-022-03154-1. View

Brownson E, Saunders J, Jatkowska A, White B, Gerasimidis K, Seenan J . Micronutrient Status and Prediction of Disease Outcome in Adults With Inflammatory Bowel Disease Receiving Biologic Therapy. Inflamm Bowel Dis. 2023; 30(8):1233-1240. PMC: 11291620. DOI: 10.1093/ibd/izad174. View

Tirosh O, Levy E, Reifen R . High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon. Nutrition. 2007; 23(11-12):878-86. DOI: 10.1016/j.nut.2007.08.019. View

Alemany-Cosme E, Saez-Gonzalez E, Moret I, Mateos B, Iborra M, Nos P . Oxidative Stress in the Pathogenesis of Crohn's Disease and the Interconnection with Immunological Response, Microbiota, External Environmental Factors, and Epigenetics. Antioxidants (Basel). 2021; 10(1). PMC: 7825667. DOI: 10.3390/antiox10010064. View

Keshteli A, Valcheva R, Nickurak C, Park H, Mandal R, van Diepen K . Anti-Inflammatory Diet Prevents Subclinical Colonic Inflammation and Alters Metabolomic Profile of Ulcerative Colitis Patients in Clinical Remission. Nutrients. 2022; 14(16). PMC: 9414437. DOI: 10.3390/nu14163294. View

Ishihara J, Arai K, Kudo T, Nambu R, Tajiri H, Aomatsu T . Serum Zinc and Selenium in Children with Inflammatory Bowel Disease: A Multicenter Study in Japan. Dig Dis Sci. 2021; 67(6):2485-2491. DOI: 10.1007/s10620-021-07078-z. View

10.

Hoekman D, Lowenberg M, van den Brink G, Ponsioen C, Benninga M, DHaens G . A prospective study comparing patient-reported outcomes in Crohn's disease. Eur J Gastroenterol Hepatol. 2019; 32(1):38-44. PMC: 6903328. DOI: 10.1097/MEG.0000000000001568. View

11.

Jarmakiewicz-Czaja S, Zielinska M, Sokal A, Filip R . Genetic and Epigenetic Etiology of Inflammatory Bowel Disease: An Update. Genes (Basel). 2022; 13(12). PMC: 9778199. DOI: 10.3390/genes13122388. View

12.

Castro Aguilar-Tablada T, Navarro-Alarcon M, Quesada Granados J, Samaniego Sanchez C, Rufian-Henares J, Nogueras-Lopez F . Ulcerative Colitis and Crohn's Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk. Nutrients. 2016; 8(12). PMC: 5188435. DOI: 10.3390/nu8120780. View

13.

Best W, Becktel J, SINGLETON J, KERN Jr F . Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976; 70(3):439-44. View

14.

Lichtiger S, Present D, Kornbluth A, Gelernt I, Bauer J, Galler G . Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med. 1994; 330(26):1841-5. DOI: 10.1056/NEJM199406303302601. View

15.

Yan W, Meihao W, Zihan S, Lingjie H, Haotian C, Qian C . Correlation Between Crohn's Disease Activity and Serum Selenium Concentration. Clin Ther. 2022; 44(5):736-743.e3. DOI: 10.1016/j.clinthera.2022.03.005. View

16.

Piatek-Guziewicz A, Pasko P, Wcislo K, Dabek-Drobny A, Przybylska-Felus M, Kaczmarczyk O . Serum levels of selected micronutrients in patients with inflammatory bowel disease in clinical remission. Pol Arch Intern Med. 2021; 131(7-8):701-708. DOI: 10.20452/pamw.15999. View

17.

Kaushal N, Kudva A, Patterson A, Chiaro C, Kennett M, Desai D . Crucial role of macrophage selenoproteins in experimental colitis. J Immunol. 2014; 193(7):3683-92. PMC: 4170023. DOI: 10.4049/jimmunol.1400347. View

18.

Martinez J, Skiba M, Chow H, Chew W, Saboda K, Lance P . A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium. Nutrients. 2021; 13(11). PMC: 8621008. DOI: 10.3390/nu13113877. View

19.

Laing B, Lim A, Ferguson L . A Personalised Dietary Approach-A Way Forward to Manage Nutrient Deficiency, Effects of the Western Diet, and Food Intolerances in Inflammatory Bowel Disease. Nutrients. 2019; 11(7). PMC: 6683058. DOI: 10.3390/nu11071532. View

20.

Finley J, DAVIS C . Selenium (Se) from high-selenium broccoli is utilized differently than selenite, selenate and selenomethionine, but is more effective in inhibiting colon carcinogenesis. Biofactors. 2001; 14(1-4):191-6. DOI: 10.1002/biof.5520140124. View