» Articles » PMID: 39455849

The Effect of Unaffected Side Resistance Training on Upper Limb Function Reconstruction and Prevention of Sarcopenia in Stroke Patients: a Randomized Controlled Trial

Overview
Journal Sci Rep
Specialty Science
Date 2024 Oct 25
PMID 39455849
Authors
Affiliations
Soon will be listed here.
Abstract

Aging has made stroke a top killer and disabler, with post-stroke sarcopenia worsening disability and quality of life. While resistance training benefits the elderly, its impact on stroke patients is understudied. This study evaluates the potential of a 4-week unilateral resistance training (URT) program to prevent sarcopenia in stroke patients. It assesses the impact of URT on hand grip strength (HG), muscle thickness (MT), upper limb functionality, and the psychological status of the patients. The study aims to quantitatively analyze these indicators to inform evidence-based post-stroke rehabilitation practices. This study employed a randomized controlled trial (RCT) involving 77 eligible stroke survivors, equally allocated into a control group (n = 39) and an intervention group (n = 38). The control group received standard rehabilitation, while the intervention group additionally underwent a 4-week URT program. The primary outcomes were unaffected side HG and MT, measuring muscle mass and function. Secondary outcomes included the Fugl-Meyer Assessment of the Upper Extremity (FMA-UE) for upper limb functionality and the Hamilton Depression Rating Scale (HAMD) for psychological well-being changes. Statistical analysis showed significant differences (p < 0. 05) in all measured parameters between the intervention and control groups after the 4-week period. Intra-group comparisons also indicated substantial improvements (p < 0. 05). Unilateral resistance training significantly mitigates muscle atrophy in stroke patients, preventing sarcopenia and enhancing upper limb function. It also ameliorates depressive symptoms, improving rehabilitation outcomes and overall quality of life.

References
1.
Voelker S, Michalopoulos N, Maier A, Reijnierse E . Reliability and Concurrent Validity of the SARC-F and Its Modified Versions: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc. 2021; 22(9):1864-1876.e16. DOI: 10.1016/j.jamda.2021.05.011. View

2.
Beaudart C, Locquet M, Reginster J, Delandsheere L, Petermans J, Bruyere O . Quality of life in sarcopenia measured with the SarQoL®: impact of the use of different diagnosis definitions. Aging Clin Exp Res. 2017; 30(4):307-313. PMC: 5876340. DOI: 10.1007/s40520-017-0866-9. View

3.
Teasell R, Salbach N, Foley N, Mountain A, Cameron J, de Jong A . Canadian Stroke Best Practice Recommendations: Rehabilitation, Recovery, and Community Participation following Stroke. 6th Edition Update 2019. Int J Stroke. 2020; 15(7):763-788. DOI: 10.1177/1747493019897843. View

4.
Lee H, Lee I, Heo J, Baik M, Park H, Lee H . Impact of Sarcopenia on Functional Outcomes Among Patients With Mild Acute Ischemic Stroke and Transient Ischemic Attack: A Retrospective Study. Front Neurol. 2022; 13:841945. PMC: 8964497. DOI: 10.3389/fneur.2022.841945. View

5.
Giuriato G, Ives S, Tarperi C, Bortolan L, Ruzzante F, Cevese A . Central and peripheral haemodynamics at exercise onset: the role of central command. Eur J Appl Physiol. 2024; 124(10):3105-3115. PMC: 11467020. DOI: 10.1007/s00421-024-05513-3. View