Talaroterpenoids A-F: Six New -Terpenoids from the Marine-Derived Fungus

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2024 Oct 25

PMID 39452883

Authors

Zi-Hong Peng

Hui Jia

Yan-Liang Luo

Li-Jun Zhang

Jia-Tong Zhou

Yuan-Han Xie

Li-Jun Wang

Jiang-Ke Qin

Jun Li

Guo-Hai Zhang

Rui-Yun Yang

Wei-Feng Xu

Affiliations

Soon will be listed here.

Abstract

Six new highly oxidized -terpenoids, including three 3--labdane type diterpenes, talaroterpenoids A-C (-), and three meroterpenoids containing an orthoester group, talaroterpenoids D-F (-), together with five known compounds (- and -), were isolated from the marine-derived fungus . Their chemical structures were elucidated through 1D, 2D NMR, HRESIMS, -based configuration analysis (JBCA), computational ECD calculations, and single-crystal X-ray diffraction analysis. Compounds and contain an unusual 6,20--lactone-bridged scaffold. Compounds and presented inhibitory effects on NO release in lipopolysaccharide (LPS)-induced BV-2 cells with IC values of 11.47 and 11.32 μM, respectively. Talaroterpenoid C () showed moderate antifungal activity against and Steyaert.

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