Stem Cells: Present Understanding and Prospects for Regenerative Dentistry

Overview

Journal J Funct Biomater

Specialty Biomedical Engineering

Date 2024 Oct 25

PMID 39452606

Authors

Angelo Michele Inchingolo

Alessio Danilo Inchingolo

Paola Nardelli

Giulia Latini

Irma Trilli

Laura Ferrante

Giuseppina Malcangi

Andrea Palermo

Francesco Inchingolo

Gianna Dipalma

Affiliations

Soon will be listed here.

Abstract

Regenerative medicine in dentistry focuses on repairing damaged oral tissues using advanced tools like stem cells, biomaterials, and tissue engineering (TE). Mesenchymal stem cells (MSCs) from dental sources, such as dental pulp and periodontal ligament, show significant potential for tissue regeneration due to their proliferative and differentiative abilities. This systematic review, following PRISMA guidelines, evaluated fifteen studies and identified effective strategies for improving dental, periodontal, and bone tissue regeneration through scaffolds, secretomes, and bioengineering methods. Key advancements include the use of dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) to boost cell viability and manage inflammation. Additionally, pharmacological agents like matrine and surface modifications on biomaterials improve stem cell adhesion and promote osteogenic differentiation. By integrating these approaches, regenerative medicine and TE can optimize dental therapies and enhance patient outcomes. This review highlights the potential and challenges in this field, providing a critical assessment of current research and future directions.

Citing Articles

The Impact of Ozone on Periodontal Cell Line Viability and Function.

Hashim N, Babiker R, Dasnadi S, Islam M, Chaitanya N, Mohammed R Curr Issues Mol Biol. 2025; 47(2).

PMID: 39996793 PMC: 11854817. DOI: 10.3390/cimb47020072.

Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors.

Dipalma G, Inchingolo A, Colonna V, Marotti P, Carone C, Ferrante L J Funct Biomater. 2025; 16(1).

PMID: 39852572 PMC: 11765672. DOI: 10.3390/jfb16010016.

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