A Multicenter Retrospective Chart Review Study Estimating the Prevalence of Iron Deficiency Anemia Among Infants, Toddlers, and Children in Riyadh, Saudi Arabia

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Oct 25

PMID 39449868

Authors

Ahmed M Almutairi

Sultan A Alwehaibi

Abdulaziz Y Almousa

Salma Alanazi

Rewaida R Bin Muaibed

Renad Althobaiti

Abdulaziz M Alkheraiji

Haya A Alamrani

Affiliations

Soon will be listed here.

Abstract

Background Iron deficiency anemia (IDA) is a prevalent nutritional disorder affecting children worldwide, leading to potential long-term cognitive and developmental deficits. This study aimed to determine the prevalence of IDA among healthy children attending Dr. Sulaiman Al-Habib Hospital Group in Riyadh, SAU, and explore the relationship between IDA and various demographic factors, including age, gender, and nationality. Methodology A retrospective chart review was conducted from July 2023 to August 2023 at Dr. Sulaiman Al-Habib Hospital Group, in Riyadh, Saudi Arabia. The study included 498 children aged 0.58 to 17 years, selected through a cluster sampling technique. Data on demographic characteristics and laboratory results, including hemoglobin (Hb) levels, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), ferritin, and RBC, were collected. Iron deficiency anemia was diagnosed based on Hb levels and other hematological indices. Statistical analysis was performed using SPSS Statistics version 23.0 (IBM Corp., Armonk, NY, USA). Results The prevalence of IDA among the study population was 9.2%, with 72.3% of the cases classified as mild and 27.7% as moderate. No cases of severe anemia were found. Infants had the highest prevalence of IDA (16.9%), followed by toddlers (12.0%), preschool children (7.2%), and school-age children (0.8%). Gender analysis revealed a prevalence of 9.7% in males and 8.6% in females, with no significant difference between genders (p = 0.659). All non-Saudi participants were free of IDA, whereas 9.3% of Saudi participants had IDA, though this difference was not statistically significant (p = 0.761). Conclusion The study found a relatively low prevalence of IDA among healthy children attending Dr. Sulaiman Al-Habib Hospital Group in Riyadh, SAU, with the highest prevalence observed among infants. These findings highlight the need for targeted interventions to prevent IDA, particularly in younger children. Routine screening and early treatment are crucial to mitigate the potential long-term effects of IDA on child development. Further research with larger and more diverse samples is recommended to validate these findings and explore additional factors influencing IDA prevalence.

References

Lozoff B, Jimenez E, Smith J . Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med. 2006; 160(11):1108-13. PMC: 1866361. DOI: 10.1001/archpedi.160.11.1108. View

DEMAEYER E . The prevalence of anaemia in the world. World Health Stat Q. 1985; 38(3):302-16. View

Zimmermann M, Hurrell R . Nutritional iron deficiency. Lancet. 2007; 370(9586):511-20. DOI: 10.1016/S0140-6736(07)61235-5. View

Ringoringo H . Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants Aged 9-11 Months. Int J Gen Med. 2022; 15:8017-8024. PMC: 9637362. DOI: 10.2147/IJGM.S383055. View

Abalkhail B, Shawky S . Prevalence of daily breakfast intake, iron deficiency anaemia and awareness of being anaemic among Saudi school students. Int J Food Sci Nutr. 2003; 53(6):519-28. DOI: 10.1080/09637480220164370. View

Torres M, Sato K, Queiroz S . [Anemia in children under 2 years in basic health care units in the State of São Paulo, Brazil]. Rev Saude Publica. 1994; 28(4):290-4. DOI: 10.1590/s0034-89101994000400008. View

Aksu T, Unal S . Iron Deficiency Anemia in Infancy, Childhood, and Adolescence. Turk Arch Pediatr. 2023; 58(4):358-362. PMC: 10440944. DOI: 10.5152/TurkArchPediatr.2023.23049. View

Burden M, Westerlund A, Armony-Sivan R, Nelson C, Jacobson S, Lozoff B . An event-related potential study of attention and recognition memory in infants with iron-deficiency anemia. Pediatrics. 2007; 120(2):e336-45. PMC: 2735131. DOI: 10.1542/peds.2006-2525. View

Puranitee P, Fuangfu S, Dumrongwongsiri O . Determination of Hemoglobin Level Among 9-Month-Old Infants Visiting Well Child Clinic. Glob Pediatr Health. 2021; 8:2333794X211036629. PMC: 8326615. DOI: 10.1177/2333794X211036629. View

10.

Kejo D, Petrucka P, Martin H, Kimanya M, Mosha T . Prevalence and predictors of anemia among children under 5 years of age in Arusha District, Tanzania. Pediatric Health Med Ther. 2018; 9:9-15. PMC: 5804135. DOI: 10.2147/PHMT.S148515. View

11.

Gupta P, Perrine C, Mei Z, Scanlon K . Iron, Anemia, and Iron Deficiency Anemia among Young Children in the United States. Nutrients. 2016; 8(6). PMC: 4924171. DOI: 10.3390/nu8060330. View

12.

Joo E, Kim K, Kim D, Lee J, Kim S . Iron deficiency anemia in infants and toddlers. Blood Res. 2017; 51(4):268-273. PMC: 5234236. DOI: 10.5045/br.2016.51.4.268. View

13.

Andriastuti M, Ilmana G, Nawangwulan S, Kosasih K . Prevalence of anemia and iron profile among children and adolescent with low socio-economic status. Int J Pediatr Adolesc Med. 2020; 7(2):88-92. PMC: 7335819. DOI: 10.1016/j.ijpam.2019.11.001. View

14.

Stefanini M, Colli C, Lerner B, Lei D, Chaves S, Di Pietro M . [Anemia and malnutrition in children at public schools in Osasco, São Paulo, Brazil]. Cad Saude Publica. 1995; 11(3):439-47. DOI: 10.1590/s0102-311x1995000300019. View

15.

Faysal W, Zaidi A, Al-Abdi S, Alhumaid S, Alshehery M, Mutair A . Hospital-Based Prevalence of Iron Deficiency Anemia among Pre-School Children in Dubai. Cureus. 2020; 12(10):e10894. PMC: 7654558. DOI: 10.7759/cureus.10894. View

16.

Gebreegziabher T, Regassa N, Wakefield M, Pritchett K, Hawk S . Disparities in the prevalence and risk factors of anaemia among children aged 6-24 months and 25-59 months in Ethiopia. J Nutr Sci. 2020; 9:e36. PMC: 7503181. DOI: 10.1017/jns.2020.29. View

17.

Bruner A, Joffe A, Duggan A, Casella J, Brandt J . Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996; 348(9033):992-6. DOI: 10.1016/S0140-6736(96)02341-0. View

18.

Al Hawsawi Z, Al-Rehali S, Mahros A, Al-Sisi A, Al-Harbi K, Yousef A . High prevalence of iron deficiency anemia in infants attending a well-baby clinic in northwestern Saudi Arabia. Saudi Med J. 2015; 36(9):1067-70. PMC: 4613630. DOI: 10.15537/smj.2015.9.11844. View

19.

Salah R, Hasab A, El-Nimr N, Tayel D . The Prevalence and Predictors of Iron Deficiency Anemia among Rural Infants in Nablus Governorate. J Res Health Sci. 2018; 18(3):e00417. PMC: 6941648. View

20.

Habib A, Kureishy S, Soofi S, Hussain I, Rizvi A, Ahmed I . Prevalence and Risk Factors for Iron Deficiency Anemia among Children under Five and Women of Reproductive Age in Pakistan: Findings from the National Nutrition Survey 2018. Nutrients. 2023; 15(15). PMC: 10421143. DOI: 10.3390/nu15153361. View