The KT Jeang Retrovirology Prize 2024: Walther Mothes

Overview

Journal Retrovirology

Publisher Biomed Central

Specialty Microbiology

Date 2024 Oct 25

PMID 39449025

Authors

Walther Mothes

Affiliations

Soon will be listed here.

References

Heinrich S, Mothes W, Brunner J, Rapoport T . The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell. 2000; 102(2):233-44. DOI: 10.1016/s0092-8674(00)00028-3. View

Papini C, Ullah I, Ranjan A, Zhang S, Wu Q, Spasov K . Proof-of-concept studies with a computationally designed M inhibitor as a synergistic combination regimen alternative to Paxlovid. Proc Natl Acad Sci U S A. 2024; 121(17):e2320713121. PMC: 11046628. DOI: 10.1073/pnas.2320713121. View

Ma X, Lu M, Gorman J, Terry D, Hong X, Zhou Z . HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. Elife. 2018; 7. PMC: 5896952. DOI: 10.7554/eLife.34271. View

Zhong P, Agosto L, Munro J, Mothes W . Cell-to-cell transmission of viruses. Curr Opin Virol. 2012; 3(1):44-50. PMC: 3587356. DOI: 10.1016/j.coviro.2012.11.004. View

Mothes W, Prehn S, Rapoport T . Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane. EMBO J. 1994; 13(17):3973-82. PMC: 395317. DOI: 10.1002/j.1460-2075.1994.tb06713.x. View

Leonhardt S, Purdy M, Grover J, Yang Z, Poulos S, McIntire W . Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry. Nat Commun. 2023; 14(1):4368. PMC: 10359404. DOI: 10.1038/s41467-023-39262-2. View

Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K . Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. Science. 2016; 352(6287):828-33. PMC: 4917739. DOI: 10.1126/science.aae0474. View

Lehmann M, Sherer N, Marks C, Pypaert M, Mothes W . Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol. 2005; 170(2):317-25. PMC: 2171413. DOI: 10.1083/jcb.200503059. View

Agosto L, Zhong P, Munro J, Mothes W . Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014; 10(2):e1003982. PMC: 3937346. DOI: 10.1371/journal.ppat.1003982. View

10.

Pertel T, Hausmann S, Morger D, Zuger S, Guerra J, Lascano J . TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011; 472(7343):361-5. PMC: 3081621. DOI: 10.1038/nature09976. View

11.

Mothes W, Boerger A, Narayan S, Cunningham J, Young J . Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein. Cell. 2000; 103(4):679-89. DOI: 10.1016/s0092-8674(00)00170-7. View

12.

Dam K, Fan C, Yang Z, Bjorkman P . Intermediate conformations of CD4-bound HIV-1 Env heterotrimers. Nature. 2023; 623(7989):1017-1025. PMC: 10686819. DOI: 10.1038/s41586-023-06639-8. View

13.

Ullah I, Escudie F, Scandale I, Gilani Z, Gendron-Lepage G, Gaudette F . Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens. iScience. 2024; 27(3):109049. PMC: 10867665. DOI: 10.1016/j.isci.2024.109049. View

14.

Mothes W, Sherer N, Jin J, Zhong P . Virus cell-to-cell transmission. J Virol. 2010; 84(17):8360-8. PMC: 2918988. DOI: 10.1128/JVI.00443-10. View

15.

Ventura J, Beloor J, Allen E, Zhang T, Haugh K, Uchil P . Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice. PLoS Pathog. 2019; 15(12):e1008161. PMC: 6917343. DOI: 10.1371/journal.ppat.1008161. View

16.

Pancera M, Zhou T, Druz A, Georgiev I, Soto C, Gorman J . Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature. 2014; 514(7523):455-61. PMC: 4348022. DOI: 10.1038/nature13808. View

17.

Gorlich D, Rapoport T . Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane. Cell. 1993; 75(4):615-30. DOI: 10.1016/0092-8674(93)90483-7. View

18.

Gorlich D, Prehn S, Hartmann E, Kalies K, Rapoport T . A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. Cell. 1992; 71(3):489-503. DOI: 10.1016/0092-8674(92)90517-g. View

19.

Ullah I, Beaudoin-Bussieres G, Symmes K, Cloutier M, Ducas E, Tauzin A . The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice. Cell Rep Med. 2022; 4(1):100893. PMC: 9799175. DOI: 10.1016/j.xcrm.2022.100893. View

20.

Li W, Chen Y, Prevost J, Ullah I, Lu M, Gong S . Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern. Cell Rep. 2021; 38(2):110210. PMC: 8673750. DOI: 10.1016/j.celrep.2021.110210. View