Punishment and Reward Sensitivity in Risk-Taking As Potential Mechanisms Explaining the Relationships Between Childhood Callous-Unemotional Traits and Adolescent Substance Use in a Longitudinal Cohort Study Sample

Overview

Journal Res Child Adolesc Psychopathol

Specialties Pediatrics
Psychiatry
Psychology

Date 2024 Oct 23

PMID 39441502

Authors

Hanna Sakki

Michelle C St Clair

Yiyun Shou

Jennifer L Allen

Affiliations

Soon will be listed here.

Abstract

Childhood callous-unemotional (CU) traits are associated with a neurocognitive response style of high reward and low punishment sensitivity, which may make these children particularly vulnerable to substance misuse. However, the mechanisms explaining the link between CU traits and substance use are poorly understood. This study investigated the mediating influences of reward and punishment sensitivity on the association between childhood CU traits and adolescent substance use. Using data from the UK Millennium Cohort Study, mediation analyses were conducted to investigate the potential indirect effects of age 14 reward and punishment sensitivity in risk-taking on the relationships between age 11 CU traits and alcohol, cannabis, and other illicit drug use at age 17. No direct effects of CU traits on substance use were found when accounting for gender, baseline alcohol use, poverty, emotional symptoms, conduct problems, hyperactivity, and verbal ability at age 11. Indirect effects of increased reward sensitivity on the relationship between CU traits and increased use were seen for alcohol, cannabis, and other drugs. There was a significant indirect effect of reduced punishment sensitivity on the relationship between CU traits and increased alcohol use, but not cannabis or other substance use. Findings suggest that reward and punishment sensitivity may have independent effects on decision-making processes contributing to adolescent substance use. Prevention and early intervention for substance use should consider modifying intervention strategies to fit the needs of adolescents with a callous interpersonal style and a neurocognitive profile characterized by a high drive for rewards and low risk aversion.

References

Vincent G, Cope L, King J, Nyalakanti P, Kiehl K . Callous-Unemotional Traits Modulate Brain Drug Craving Response in High-Risk Young Offenders. J Abnorm Child Psychol. 2017; 46(5):993-1009. PMC: 5949254. DOI: 10.1007/s10802-017-0364-8. View

Kim-Spoon J, Deater-Deckard K, Holmes C, Lee J, Chiu P, King-Casas B . Behavioral and neural inhibitory control moderates the effects of reward sensitivity on adolescent substance use. Neuropsychologia. 2016; 91:318-326. PMC: 5075251. DOI: 10.1016/j.neuropsychologia.2016.08.028. View

Swendsen J, Burstein M, Case B, Conway K, Dierker L, He J . Use and abuse of alcohol and illicit drugs in US adolescents: results of the National Comorbidity Survey-Adolescent Supplement. Arch Gen Psychiatry. 2012; 69(4):390-8. PMC: 3746542. DOI: 10.1001/archgenpsychiatry.2011.1503. View

Kosterman R, Hawkins J, Guo J, Catalano R, Abbott R . The dynamics of alcohol and marijuana initiation: patterns and predictors of first use in adolescence. Am J Public Health. 2000; 90(3):360-6. PMC: 1446176. DOI: 10.2105/ajph.90.3.360. View

Feinstein E, Richter L, Foster S . Addressing the critical health problem of adolescent substance use through health care, research, and public policy. J Adolesc Health. 2012; 50(5):431-6. DOI: 10.1016/j.jadohealth.2011.12.033. View

Rogers R, Everitt B, Baldacchino A, Blackshaw A, Swainson R, Wynne K . Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology. 1999; 20(4):322-39. DOI: 10.1016/S0893-133X(98)00091-8. View

Ray J, Frick P . Assessing Callous-Unemotional Traits Using the Total Score from the Inventory of Callous-Unemotional Traits: A Meta-Analysis. J Clin Child Adolesc Psychol. 2018; 49(2):190-199. DOI: 10.1080/15374416.2018.1504297. View

Podsakoff P, Mackenzie S, Podsakoff N . Sources of method bias in social science research and recommendations on how to control it. Annu Rev Psychol. 2011; 63:539-69. DOI: 10.1146/annurev-psych-120710-100452. View

Sakki H, St Clair M, Hwang S, Allen J . The association between callous-unemotional traits and substance use in childhood and adolescence: A systematic review and meta-analysis. J Affect Disord. 2023; 338:502-517. DOI: 10.1016/j.jad.2023.06.051. View

10.

Winters D, Brandon-Friedman R, Yepes G, Hinckley J . Systematic review and meta-analysis of socio-cognitive and socio-affective processes association with adolescent substance use. Drug Alcohol Depend. 2021; 219:108479. PMC: 7943258. DOI: 10.1016/j.drugalcdep.2020.108479. View

11.

Waller R, Hicks B . Trajectories of alcohol and marijuana use among primary versus secondary psychopathy variants within an adjudicated adolescent male sample. Personal Disord. 2018; 10(1):87-96. PMC: 6318045. DOI: 10.1037/per0000303. View

12.

Frick P, Bodin S, Barry C . Psychopathic traits and conduct problems in community and clinic-referred samples of children: further development of the psychopathy screening device. Psychol Assess. 2001; 12(4):382-93. View

13.

Kimonis E, Frick P, Skeem J, Marsee M, Cruise K, Munoz L . Assessing callous-unemotional traits in adolescent offenders: validation of the Inventory of Callous-Unemotional Traits. Int J Law Psychiatry. 2008; 31(3):241-52. DOI: 10.1016/j.ijlp.2008.04.002. View

14.

Poon K . Hot and Cool Executive Functions in Adolescence: Development and Contributions to Important Developmental Outcomes. Front Psychol. 2018; 8:2311. PMC: 5767838. DOI: 10.3389/fpsyg.2017.02311. View

14.

Chen S, Deng Z, Xu Y, Long Q, Yang J, Yuan J . Individual Differences in Spontaneous Expressive Suppression Predict Amygdala Responses to Fearful Stimuli: The Role of Suppression Priming. Front Psychol. 2017; 8:1. PMC: 5281595. DOI: 10.3389/fpsyg.2017.00001. View

15.

Byrd A, Loeber R, Pardini D . Antisocial behavior, psychopathic features and abnormalities in reward and punishment processing in youth. Clin Child Fam Psychol Rev. 2013; 17(2):125-56. PMC: 5330364. DOI: 10.1007/s10567-013-0159-6. View

16.

Forrest C, Gibson J, Halligan S, St Clair M . A Cross-Lagged Analysis of Emotion Regulation, Peer Problems, and Emotional Problems in Children With and Without Early Language Difficulties: Evidence From the Millennium Cohort Study. J Speech Lang Hear Res. 2020; 63(4):1227-1239. DOI: 10.1044/2020_JSLHR-19-00188. View

17.

Connelly R, Platt L . Cohort profile: UK Millennium Cohort Study (MCS). Int J Epidemiol. 2014; 43(6):1719-25. DOI: 10.1093/ije/dyu001. View

18.

Braddock K, Dillard J, Voigt D, Stephenson M, Sopory P, Anderson J . Impulsivity partially mediates the relationship between BIS/BAS and risky health behaviors. J Pers. 2011; 79(4):793-810. DOI: 10.1111/j.1467-6494.2011.00699.x. View

19.

Gray K, Squeglia L . Research Review: What have we learned about adolescent substance use?. J Child Psychol Psychiatry. 2017; 59(6):618-627. PMC: 5771977. DOI: 10.1111/jcpp.12783. View