Construction of Frailty and Risk Prediction Models in Maintenance Hemodialysis Patients: a Cross-sectional Study

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Oct 23

PMID 39440043

Authors

Huan Liu

Mingfen Tao

Man Zhang

Zhiqing Zhou

Yang Ni

Qin Wang

Xiang Zhang

Chenru Chi

Dan Yang

Mengqi Chen

Xiubin Tao

Ming Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: As the prevalence of diabetic nephropathy and hypertensive nephropathy increases with age in mainland China, the number of patients with end-stage renal disease is increasing, leading to an increase in the number of patients receiving maintenance hemodialysis. Considering the harmful effects of frailty on the health of maintenance hemodialysis patients, this study aims to identify hemodialysis patients at risk for frailty at an early stage, in order to prevent or delay the progression of frailty in the early stage, so as to prevent the adverse consequences of frailty.

Methods: A total of 479 patients admitted to the blood purification centers of two grade tertiary hospitals in Anhui Province, China, using convenient sampling. The Frailty Scale, the SARC-F questionnaire, the Simplified Food Appetite Questionnaire (SNAQ) and the mini nutritional assessment short-form (MNA-SF) were used in the study. Pearson correlation analysis was used to explore the correlation among the frailty influencing factors.

Results: The incidence of frailty was 24.0% among 479 Chinese hemodialysis patients. Gender ( < 0.05), Malnutrition ( < 0.001), sarcopenia ( < 0.001), and feel tired after dialysis ( < 0.001) were highly correlated with frailty in Chinese hemodialysis patients. Serum albumin concentration ( < 0.05) was a protective factor of frailty.

Conclusion: This survey shows that frailty was highly prevalent among Chinese hemodialysis patients. Medical staff and their families should make early judgments and carry out interventions on the risk of frailty.

References

Liyanage T, Ninomiya T, Jha V, Neal B, Patrice H, Okpechi I . Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015; 385(9981):1975-82. DOI: 10.1016/S0140-6736(14)61601-9. View

Schwenk M, Mohler J, Wendel C, DHuyvetter K, Fain M, Taylor-Piliae R . Wearable sensor-based in-home assessment of gait, balance, and physical activity for discrimination of frailty status: baseline results of the Arizona frailty cohort study. Gerontology. 2014; 61(3):258-67. PMC: 4452118. DOI: 10.1159/000369095. View

Bossola M, Ciciarelli C, Di Stasio E, Panocchia N, Conte G, Rosa F . Relationship between appetite and symptoms of depression and anxiety in patients on chronic hemodialysis. J Ren Nutr. 2011; 22(1):27-33. DOI: 10.1053/j.jrn.2011.02.005. View

Cruz-Jentoft A, Sayer A . Sarcopenia. Lancet. 2019; 393(10191):2636-2646. DOI: 10.1016/S0140-6736(19)31138-9. View

Lochs H, Allison S, Meier R, Pirlich M, Kondrup J, Schneider S . Introductory to the ESPEN Guidelines on Enteral Nutrition: Terminology, definitions and general topics. Clin Nutr. 2006; 25(2):180-6. DOI: 10.1016/j.clnu.2006.02.007. View

Zabel R, Ash S, King N, Juffs P, Bauer J . Relationships between appetite and quality of life in hemodialysis patients. Appetite. 2012; 59(1):194-9. DOI: 10.1016/j.appet.2012.02.016. View

Zukeran M, Aprahamian I, Vicente B, Lima Ribeiro S . PORTUGUESE VERSION OF THE SNAQ QUESTIONNAIRE: TRANSLATION AND CULTURAL ADAPTATION. Arq Gastroenterol. 2020; 57(2):178-181. DOI: 10.1590/S0004-2803.202000000-33. View

Kojima G . Frailty as a Predictor of Nursing Home Placement Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. J Geriatr Phys Ther. 2016; 41(1):42-48. DOI: 10.1519/JPT.0000000000000097. View

Chan G, Ng J, Chow K, Kwong V, Pang W, Cheng P . Progression in Physical Frailty in Peritoneal Dialysis Patients. Kidney Blood Press Res. 2021; 46(3):342-351. DOI: 10.1159/000515635. View

10.

Kalyoncuoglu M, Durmus G . Relationship between C-reactive protein-to-albumin ratio and the extent of coronary artery disease in patients with non-ST-elevated myocardial infarction. Coron Artery Dis. 2019; 31(2):130-136. DOI: 10.1097/MCA.0000000000000768. View

11.

Bai A, Agostini F, Bernetti A, Mangone M, Fidenzi G, DUrzo R . State of the evidence about rehabilitation interventions in patients with dysphagia. Eur J Phys Rehabil Med. 2021; 57(6):900-911. DOI: 10.23736/S1973-9087.21.06716-2. View

12.

Doris Miu K, Lam P . Effects of Nutritional Status on 6-Month Outcome of Hip Fractures in Elderly Patients. Ann Rehabil Med. 2018; 41(6):1005-1012. PMC: 5773420. DOI: 10.5535/arm.2017.41.6.1005. View

13.

Daniel S, Azuero A, Gutierrez O, Heaton K . Examining the relationship between nutrition, quality of life, and depression in hemodialysis patients. Qual Life Res. 2020; 30(3):759-768. DOI: 10.1007/s11136-020-02684-2. View

14.

Drapeau V, King N, Hetherington M, Doucet E, Blundell J, Tremblay A . Appetite sensations and satiety quotient: predictors of energy intake and weight loss. Appetite. 2006; 48(2):159-66. DOI: 10.1016/j.appet.2006.08.002. View

15.

Fang Q, Zhu G, Huang J, Pan S, Fang M, Li Q . Current Status of Sarcopenia in the Disabled Elderly of Chinese Communities in Shanghai: Based on the Updated EWGSOP Consensus for Sarcopenia. Front Med (Lausanne). 2020; 7:552415. PMC: 7689196. DOI: 10.3389/fmed.2020.552415. View

16.

Horwich T, Kalantar-Zadeh K, MacLellan R, Fonarow G . Albumin levels predict survival in patients with systolic heart failure. Am Heart J. 2008; 155(5):883-9. DOI: 10.1016/j.ahj.2007.11.043. View

17.

Gama-Axelsson T, Lindholm B, Barany P, Heimburger O, Stenvinkel P, Qureshi A . Self-rated appetite as a predictor of mortality in patients with stage 5 chronic kidney disease. J Ren Nutr. 2012; 23(2):106-13. DOI: 10.1053/j.jrn.2012.04.009. View

18.

Wang Y, Liang C, Chou M, Chiu C, Lin H, Hsu Y . The Effectiveness of Frailty Intervention for Older Patients with Frailty during Hospitalization. J Nutr Health Aging. 2023; 27(6):413-420. DOI: 10.1007/s12603-023-1924-y. View

19.

Eroglu A . Malnutrition and the heart. Turk Pediatri Ars. 2019; 54(3):139-140. PMC: 6776449. DOI: 10.14744/TurkPediatriArs.2019.03764. View

20.

de Sire A, Giachero A, DE Santi S, Inglese K, Solaro C . Screening dysphagia risk in 534 older patients undergoing rehabilitation after total joint replacement: a cross-sectional study. Eur J Phys Rehabil Med. 2020; 57(1):131-136. DOI: 10.23736/S1973-9087.20.06321-2. View