One Year of Heavy Resistance Training Modifies Muscle Fiber Characteristics in the Elderly

Overview

Journal Sports Med Int Open

Publisher Thieme

Specialty Orthopedics

Date 2024 Oct 23

PMID 39439846

Authors

Anne Theil Gates

Michael Kjaer

Jesper Loevind Andersen

Affiliations

Soon will be listed here.

Abstract

Physical function declines with age, accelerating during the 6th decade of life, primarily due to loss in muscle mass and strength. The present study aimed to investigate the effect of one year of heavy resistance training in older adults (62-70 years) on muscle mass and strength. Further, we investigated muscle characteristics after the intervention by obtaining muscle biopsies from the vastus lateralis to compare muscle fiber characteristics between the heavy resistance training (HRT) (n=10) and the sedentary control group (CON) (n=10). We found that one year of resistance training increased isometric muscle strength (p<0.0001, ES: 2.43 (Hedges' g)) and lean body mass (p<0.05, ES: 0.96), whereas cross-sectional area of the vastus lateralis and lean leg mass were unaltered. At year 1, the percentage of type IIX muscle fibers was lower in HRT compared to CON (p<0.05, ES: 0.99), whereas the muscle fiber size did not differ between groups for the major fiber types (I and II). In conclusion, one year of resistance training in elderly improved muscle strength and lean body mass but not cross-sectional area and lean leg mass. This indicates that the increase in muscle strength may be caused by neuromuscular adaptations rather than morphological muscle tissue changes per se.

References

Andersen J, Aagaard P . Effects of strength training on muscle fiber types and size; consequences for athletes training for high-intensity sport. Scand J Med Sci Sports. 2010; 20 Suppl 2:32-8. DOI: 10.1111/j.1600-0838.2010.01196.x. View

Brooke M, Kaiser K . Muscle fiber types: how many and what kind?. Arch Neurol. 1970; 23(4):369-79. DOI: 10.1001/archneur.1970.00480280083010. View

Verdijk L, Snijders T, Holloway T, van Kranenburg J, van Loon L . Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men. Med Sci Sports Exerc. 2016; 48(11):2157-2164. DOI: 10.1249/MSS.0000000000001019. View

Skelton D, Greig C, Davies J, Young A . Strength, power and related functional ability of healthy people aged 65-89 years. Age Ageing. 1994; 23(5):371-7. DOI: 10.1093/ageing/23.5.371. View

Lee I, Shiroma E, Lobelo F, Puska P, Blair S, Katzmarzyk P . Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012; 380(9838):219-29. PMC: 3645500. DOI: 10.1016/S0140-6736(12)61031-9. View

Eriksen C, Garde E, Reislev N, Wimmelmann C, Bieler T, Ziegler A . Physical activity as intervention for age-related loss of muscle mass and function: protocol for a randomised controlled trial (the LISA study). BMJ Open. 2016; 6(12):e012951. PMC: 5168596. DOI: 10.1136/bmjopen-2016-012951. View

Andersen L, Andersen J, Magnusson S, Suetta C, Madsen J, Christensen L . Changes in the human muscle force-velocity relationship in response to resistance training and subsequent detraining. J Appl Physiol (1985). 2005; 99(1):87-94. DOI: 10.1152/japplphysiol.00091.2005. View

Moro T, Brightwell C, Volpi E, Rasmussen B, Fry C . Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. J Appl Physiol (1985). 2020; 128(4):795-804. PMC: 7191507. DOI: 10.1152/japplphysiol.00723.2019. View

Churchward-Venne T, Tieland M, Verdijk L, Leenders M, Dirks M, de Groot L . There Are No Nonresponders to Resistance-Type Exercise Training in Older Men and Women. J Am Med Dir Assoc. 2015; 16(5):400-11. DOI: 10.1016/j.jamda.2015.01.071. View

10.

Wang E, Nyberg S, Hoff J, Zhao J, Leivseth G, Torhaug T . Impact of maximal strength training on work efficiency and muscle fiber type in the elderly: Implications for physical function and fall prevention. Exp Gerontol. 2017; 91:64-71. DOI: 10.1016/j.exger.2017.02.071. View

11.

Suetta C, Haddock B, Alcazar J, Noerst T, Hansen O, Ludvig H . The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years. J Cachexia Sarcopenia Muscle. 2019; 10(6):1316-1329. PMC: 6903448. DOI: 10.1002/jcsm.12477. View

12.

Gylling A, Eriksen C, Garde E, Wimmelmann C, Reislev N, Bieler T . The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults. Exp Gerontol. 2020; 136:110939. DOI: 10.1016/j.exger.2020.110939. View

13.

Bickel C, Cross J, Bamman M . Exercise dosing to retain resistance training adaptations in young and older adults. Med Sci Sports Exerc. 2010; 43(7):1177-87. DOI: 10.1249/MSS.0b013e318207c15d. View

14.

Rhea M . Determining the magnitude of treatment effects in strength training research through the use of the effect size. J Strength Cond Res. 2004; 18(4):918-20. DOI: 10.1519/14403.1. View

15.

Mayhew D, Kim J, Cross J, Ferrando A, Bamman M . Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans. J Appl Physiol (1985). 2009; 107(5):1655-62. PMC: 2777794. DOI: 10.1152/japplphysiol.91234.2008. View

16.

Kosek D, Kim J, Petrella J, Cross J, Bamman M . Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol (1985). 2006; 101(2):531-44. DOI: 10.1152/japplphysiol.01474.2005. View

17.

Nilwik R, Snijders T, Leenders M, Groen B, van Kranenburg J, Verdijk L . The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size. Exp Gerontol. 2013; 48(5):492-8. DOI: 10.1016/j.exger.2013.02.012. View

18.

Mackey A, Esmarck B, Kadi F, Koskinen S, Kongsgaard M, Sylvestersen A . Enhanced satellite cell proliferation with resistance training in elderly men and women. Scand J Med Sci Sports. 2007; 17(1):34-42. DOI: 10.1111/j.1600-0838.2006.00534.x. View

19.

Holm L, Reitelseder S, Pedersen T, Doessing S, Petersen S, Flyvbjerg A . Changes in muscle size and MHC composition in response to resistance exercise with heavy and light loading intensity. J Appl Physiol (1985). 2008; 105(5):1454-61. DOI: 10.1152/japplphysiol.90538.2008. View

20.

Campbell M, McComas A, Petito F . Physiological changes in ageing muscles. J Neurol Neurosurg Psychiatry. 1973; 36(2):174-82. PMC: 1083551. DOI: 10.1136/jnnp.36.2.174. View