The Host Cells Suppress the Proliferation of Pseudorabies Virus by Regulating the PI3K/Akt/mTOR Pathway

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2024 Oct 22

PMID 39436133

Authors

Lei Xu

Qian Tao

Yang Zhang

Feng-Qin Lee

Tong Xu

Li-Shuang Deng

Zhi-Jie Jian

Jun Zhao

Si-Yuan Lai

Yuan-Cheng Zhou

Ling Zhu

Zhi-Wen Xu

Affiliations

Soon will be listed here.

Abstract

Importance: PRV, known for its neurotropic properties, is capable of inducing severe neuronal damage. Our study discovered that following PRV infection, the expression of MMP2 was upregulated, leading to the degradation of ZO-1. Furthermore, upon PRV infection in the host, the promoter of TIMP1 is significantly activated, resulting in a significant increase in TIMP1 protein levels. This upregulation of TIMP1 inhibits the proliferation of PRV through the PI3K/Akt signaling pathway. This study elucidated the mechanism through which PRV, including the PRV XJ delgE/gI/TK strains, compromises the blood-brain barrier and identifies the antiviral response characterized by the activation of the PI3K/Akt signaling pathway within infected host cells. These findings provide potential therapeutic targets for the clinical management and treatment of PRV.

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