Comprehensive Phage Display Viral Antibody Profiling Using VirScan: Potential Applications in Chronic Immune-mediated Disease

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2024 Oct 21

PMID 39431820

Authors

Jed Valentiner Shrewsbury

Evangelin Shaloom Vitus

Adam Leslie Koziol

Anna Nenarokova

Tine Jess

Rahma Elmahdi

Affiliations

Soon will be listed here.

Abstract

Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensive quantification of past viral exposures. We review its use in immune-mediated diseases (IMDs), highlighting its utility in identifying viral exposures in the context of IMD development. Finally, we evaluate its potential for precision medicine by integrating it with other large-scale omics data sets.

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