» Articles » PMID: 39430389

Current State of Spinal Nerve Sheath Tumor Management and Future Advances

Overview
Journal Neurooncol Adv
Date 2024 Oct 21
PMID 39430389
Authors
Affiliations
Soon will be listed here.
Abstract

Nerve sheath tumors are the most common tumors of the spine after meningiomas. They include schwannomas, neurofibroma, and malignant peripheral nerve sheath tumors. These can arise sporadically or in association with tumor predisposition syndromes, including neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. Though surgery is the traditional mainstay of treatment for these tumors, the discovery of the genetic and molecular basis of these diseases in recent decades has prompted investigation into targeted therapies. Here, we give a clinical overview of spinal nerve sheath tumors, their imaging features, current management practices, and explore ongoing advances in systemic therapies.

References
1.
Chou D, Bilsky M, Luzzati A, Fisher C, Ziya L Gokaslan , Rhines L . Malignant peripheral nerve sheath tumors of the spine: results of surgical management from a multicenter study. J Neurosurg Spine. 2016; 26(3):291-298. DOI: 10.3171/2016.8.SPINE151548. View

2.
Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada C, Lin M . PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet. 2014; 46(11):1227-32. PMC: 4249650. DOI: 10.1038/ng.3095. View

3.
Shin D, Sohn M, Kim H, Lee D, Jeon S, Hwang Y . Clinical analysis of spinal stereotactic radiosurgery in the treatment of neurogenic tumors. J Neurosurg Spine. 2015; 23(4):429-37. DOI: 10.3171/2015.1.SPINE14910. View

4.
Judson I, Verweij J, Gelderblom H, Hartmann J, Schoffski P, Blay J . Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. Lancet Oncol. 2014; 15(4):415-23. DOI: 10.1016/S1470-2045(14)70063-4. View

5.
Koike H, Nishida Y, Ito S, Shimoyama Y, Ikuta K, Urakawa H . Diffusion-Weighted Magnetic Resonance Imaging Improves the Accuracy of Differentiation of Benign from Malignant Peripheral Nerve Sheath Tumors. World Neurosurg. 2021; 157:e207-e214. DOI: 10.1016/j.wneu.2021.09.130. View