Dynamic Contrast Enhanced High Field Magnetic Resonance Imaging for Canine Primary Intracranial Neoplasia

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2024 Oct 21

PMID 39430382

Authors

Simon Choi

Caterina Brighi

Sam Long

Affiliations

Soon will be listed here.

Abstract

Introduction: Distinguishing meningiomas from other intracranial neoplasms is clinically relevant as the prognostic and therapeutic implications differ greatly and influence clinical decision making. Dynamic contrast-enhanced MRI (DCE-MRI) is an imaging technique that assists with characterisation of physiologic alterations such as blood flow and tissue vascular permeability. Quantitative pharmacokinetic analysis utilising DCE-MRI has not been studied in canine neuro-oncology.

Methods: A retrospective study was performed in canine patients that underwent DCE-MRI with an imaging diagnosis of an intracranial meningioma and surgery for histopathological diagnosis. Kinetic parameters Ktrans and cerebral blood flow were measured and compared to assess whether differences could be identified between meningiomas and other intracranial neoplasms.

Results: Six dogs with meningiomas and 3 dogs with other intracranial neoplasms were included for statistical analysis. Cerebral blood flow values were found to be statistically higher within meningiomas compared to other intracranial neoplasms. Ktrans values were higher within meningiomas than in other types of intracranial tumours, however this difference did not reach statistical significance.

Discussion: Based on the results of this study cerebral blood flow measurement can be utilised to differentiate canine intracranial meningiomas from other similar appearing intracranial tumours.

References

Shinn R, Hollingsworth C, Parker R, Rossmeisl J, Werre S . Comparison of stereotactic brain biopsy techniques in dogs: neuronavigation, 3D-printed guides, and neuronavigation with 3D-printed guides. Front Vet Sci. 2024; 11:1406928. PMC: 11194692. DOI: 10.3389/fvets.2024.1406928. View

Fujii K, Fujita N, Hirabuki N, Hashimoto T, Miura T, Kozuka T . Neuromas and meningiomas: evaluation of early enhancement with dynamic MR imaging. AJNR Am J Neuroradiol. 1992; 13(4):1215-20. PMC: 8333595. View

Pollard R, Reilly C, Uerling M, Wood F, Feldman E . Cross-sectional imaging characteristics of pituitary adenomas, invasive adenomas and adenocarcinomas in dogs: 33 cases (1988-2006). J Vet Intern Med. 2009; 24(1):160-5. DOI: 10.1111/j.1939-1676.2009.0414.x. View

DORN C, Taylor D, Schneider R, Hibbard H, Klauber M . Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst. 1968; 40(2):307-18. View

Gutmann S, Winkler D, Muller M, Mobius R, Fischer J, Bottcher P . Accuracy of a magnetic resonance imaging-based 3D printed stereotactic brain biopsy device in dogs. J Vet Intern Med. 2020; 34(2):844-851. PMC: 7096628. DOI: 10.1111/jvim.15739. View

Cervera V, Mai W, Vite C, Johnson V, Dayrell-Hart B, Seiler G . Comparative magnetic resonance imaging findings between gliomas and presumed cerebrovascular accidents in dogs. Vet Radiol Ultrasound. 2011; 52(1):33-40. View

Tofts P, Kermode A . Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn Reson Med. 1991; 17(2):357-67. DOI: 10.1002/mrm.1910170208. View

Essig M, Shiroishi M, Nguyen T, Saake M, Provenzale J, Enterline D . Perfusion MRI: the five most frequently asked technical questions. AJR Am J Roentgenol. 2012; 200(1):24-34. PMC: 3593114. DOI: 10.2214/AJR.12.9543. View

Zhang H, Rodiger L, Shen T, Miao J, Oudkerk M . Perfusion MR imaging for differentiation of benign and malignant meningiomas. Neuroradiology. 2008; 50(6):525-30. PMC: 2440923. DOI: 10.1007/s00234-008-0373-y. View

10.

Mariani C, Jennings M, Olby N, Borst L, Brown Jr J, Robertson I . Histiocytic sarcoma with central nervous system involvement in dogs: 19 cases (2006-2012). J Vet Intern Med. 2015; 29(2):607-13. PMC: 4895499. DOI: 10.1111/jvim.12554. View

11.

Boss M, Muradyan N, Thrall D . DCE-MRI: a review and applications in veterinary oncology. Vet Comp Oncol. 2012; 11(2):87-100. PMC: 3593756. DOI: 10.1111/j.1476-5829.2011.00305.x. View

12.

Platt S, Scase T, Adams V, Wieczorek L, Miller J, Adamo F . Vascular endothelial growth factor expression in canine intracranial meningiomas and association with patient survival. J Vet Intern Med. 2006; 20(3):663-8. DOI: 10.1892/0891-6640(2006)20[663:vegfei]2.0.co;2. View

13.

Meneses F, Maiolini A, Forterre F, Oevermann A, Schweizer-Gorgas D . Feasability of a Frameless Brain Biopsy System for Companion Animals Using Cone-Beam CT-Based Automated Registration. Front Vet Sci. 2022; 8:779845. PMC: 8863864. DOI: 10.3389/fvets.2021.779845. View

14.

LaRue M, Taylor A, Back A, Lindley S, Boudreaux B, Almond G . Central nervous system lymphoma in 18 dogs (2001 to 2015). J Small Anim Pract. 2018; 59(9):547-552. DOI: 10.1111/jsap.12868. View

15.

Bentley R . Magnetic resonance imaging diagnosis of brain tumors in dogs. Vet J. 2015; 205(2):204-16. DOI: 10.1016/j.tvjl.2015.01.025. View

16.

Thomovsky S, Packer R, Burcham G, Heng H . Imaging diagnosis-magnetic resonance imaging features of metastatic cerebral lymphoma in a dog. Vet Radiol Ultrasound. 2011; 52(2):192-5. DOI: 10.1111/j.1740-8261.2010.01768.x. View

17.

Mai W, Burke E, Reetz J, Hecht S, Paek M, Church M . High-field MRI using standard pulse sequences has moderate to substantial interobserver agreement and good accuracy for differentiation between intracranial extra-axial histiocytic sarcoma and meningioma in dogs. Vet Radiol Ultrasound. 2021; 63(2):176-184. DOI: 10.1111/vru.13038. View

18.

Snyder J, Shofer F, Van Winkle T, Massicotte C . Canine intracranial primary neoplasia: 173 cases (1986-2003). J Vet Intern Med. 2006; 20(3):669-75. DOI: 10.1892/0891-6640(2006)20[669:cipnc]2.0.co;2. View

19.

Nowosielski M, Galldiks N, Iglseder S, Kickingereder P, von Deimling A, Bendszus M . Diagnostic challenges in meningioma. Neuro Oncol. 2017; 19(12):1588-1598. PMC: 5716093. DOI: 10.1093/neuonc/nox101. View

20.

Anwer C, Vernau K, Higgins R, Dickinson P, Sturges B, LeCouteur R . Magnetic resonance imaging features of intracranial granular cell tumors in six dogs. Vet Radiol Ultrasound. 2013; 54(3):271-7. DOI: 10.1111/vru.12027. View