Suicide Risk in Juvenile Open Angle Glaucoma Patients

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2024 Oct 21

PMID 39430028

Authors

Hye-Jeong Seong

Sukyoung Jung

Sooyeon Choe

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the association between juvenile open angle glaucoma (JOAG) and mental health among Koreans.

Methods: This study used nationally representative data from the 8 Korea National Health and Nutrition Examination Survey (KNHANES) 2021. Glaucoma diagnosis followed the International Society of Geographical and Epidemiological Ophthalmology criteria based on glaucomatous structural defects, visual field defects, corrected vision, and intraocular pressure. As outcomes, suicidal behaviors, psychiatric counseling, and depression were evaluated through mental health questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using logistic regression models, adjusting for covariates.

Results: Among 7090 participants, 3446 met the inclusion criteria for analysis, and 88 (2.6%) were diagnosed with open angle glaucoma (OAG). After adjusting for age, sex, and best-corrected visual acuity (VA), participants with OAG were revealed to have significantly higher odds of suicidal behaviors (, ideation, planning, or attempts) compared with those without OAG (OR: 2.70; 95%CI: 1.12-6.54; =0.028). This association remained significant after further adjustments for socioeconomic status, lifestyle factors, and presence of chronic conditions (=0.031 and 0.035, respectively). However, there was no significant difference for the other two outcomes, psychiatric counseling and depression. An age-stratified analysis revealed a stronger association between OAG and suicidal behaviors in younger JOAG participants (<40y) than in older OAG participants (≥40y; OR: 3.80 2.22; 95%CI: 0.79-18.22 0.56-8.80, respectively).

Conclusion: OAG patients show a higher risk of suicidal behaviors than those without glaucoma particularly in JOAG patients.

References

Wang S, Singh K, Lin S . Prevalence and predictors of depression among participants with glaucoma in a nationally representative population sample. Am J Ophthalmol. 2012; 154(3):436-444.e2. PMC: 3422443. DOI: 10.1016/j.ajo.2012.03.039. View

Chen Y, Lai Y, Wang J, Shen Y, Wang C, Chen H . The association between glaucoma and risk of depression: a nationwide population-based cohort study. BMC Ophthalmol. 2018; 18(1):146. PMC: 6013853. DOI: 10.1186/s12886-018-0811-5. View

Selvan H, Gupta S, Wiggs J, Gupta V . Juvenile-onset open-angle glaucoma - A clinical and genetic update. Surv Ophthalmol. 2021; 67(4):1099-1117. PMC: 9192165. DOI: 10.1016/j.survophthal.2021.09.001. View

Kim H, Lee E, Ahn S, Kim K, Kim H, Kim J . The 2022 focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension. Clin Hypertens. 2023; 29(1):11. PMC: 9930285. DOI: 10.1186/s40885-023-00234-9. View

Osuagwu U, Ahaiwe K, Meribe N, Nkanga E, Ekpenyong B, Ibanga A . Quality of life and depression among patients with high myopia in Nigeria: a cross sectional study. Int J Ophthalmol. 2023; 16(12):2071-2081. PMC: 10700079. DOI: 10.18240/ijo.2023.12.21. View

Dayal A, Sodimalla K, Chelerkar V, Deshpande M . Prevalence of Anxiety and Depression in Patients With Primary Glaucoma in Western India. J Glaucoma. 2021; 31(1):37-40. DOI: 10.1097/IJG.0000000000001935. View

Gaynes B, West S, Ford C, Frame P, Klein J, Lohr K . Screening for suicide risk in adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2004; 140(10):822-35. DOI: 10.7326/0003-4819-140-10-200405180-00015. View

Kim C, Seong G, Lee N, Song K . Prevalence of primary open-angle glaucoma in central South Korea the Namil study. Ophthalmology. 2011; 118(6):1024-30. DOI: 10.1016/j.ophtha.2010.10.016. View

Stamatiou M, Kazantzis D, Theodossiadis P, Chatziralli I . Depression in glaucoma patients: A review of the literature. Semin Ophthalmol. 2021; 37(1):29-35. DOI: 10.1080/08820538.2021.1903945. View

10.

Foster P, Buhrmann R, Quigley H, Johnson G . The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol. 2002; 86(2):238-42. PMC: 1771026. DOI: 10.1136/bjo.86.2.238. View

11.

Gamiochipi-Arjona J, Azses-Halabe Y, Tolosa-Tort P, Lazcano-Gomez G, Gonzalez-Salinas R, Turati-Acosta M . Depression and Medical Treatment Adherence in Mexican Patients With Glaucoma. J Glaucoma. 2020; 30(3):251-256. DOI: 10.1097/IJG.0000000000001739. View

12.

Zhang X, Olson D, Le P, Lin F, Fleischman D, Davis R . The Association Between Glaucoma, Anxiety, and Depression in a Large Population. Am J Ophthalmol. 2017; 183:37-41. DOI: 10.1016/j.ajo.2017.07.021. View

13.

Park J, Cho S, Lee J, Hwang J, Kim J, Kim B . Association between employment status and sickness presenteeism among Korean employees: a cross-sectional study. Ann Occup Environ Med. 2020; 32:e17. PMC: 7332349. DOI: 10.35371/aoem.2020.32.e17. View

14.

Song S, Choi K, Han J, Jee D, Jeoung J, Jo Y . Methodology and Rationale for Ophthalmic Examinations in the Seventh and Eighth Korea National Health and Nutrition Examination Surveys (2017-2021). Korean J Ophthalmol. 2021; 35(4):295-303. PMC: 8357612. DOI: 10.3341/kjo.2021.0016. View

15.

Seo M, Lee W, Kim S, Kang J, Kang J, Kim K . 2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea. J Obes Metab Syndr. 2019; 28(1):40-45. PMC: 6484940. DOI: 10.7570/jomes.2019.28.1.40. View

16.

Sun Y, Chen A, Zou M, Zhang Y, Jin L, Li Y . Time trends, associations and prevalence of blindness and vision loss due to glaucoma: an analysis of observational data from the Global Burden of Disease Study 2017. BMJ Open. 2022; 12(1):e053805. PMC: 8739070. DOI: 10.1136/bmjopen-2021-053805. View

17.

Chen H, Lin C, Kao C . Long-Term Use of Selective Serotonin Reuptake Inhibitors and Risk of Glaucoma in Depression Patients. Medicine (Baltimore). 2015; 94(45):e2041. PMC: 4912305. DOI: 10.1097/MD.0000000000002041. View

18.

Bae J, Han K, Ko S, Yang Y, Choi J, Choi K . Diabetes Fact Sheet in Korea 2021. Diabetes Metab J. 2022; 46(3):417-426. PMC: 9171160. DOI: 10.4093/dmj.2022.0106. View

19.

Ha A, Kim S, Kang G, Yoon H, Kim Y . Association between Sight-Threatening Eye Diseases and Death by Suicide in South Korea: A Nationwide Population-based Cohort Study. Ophthalmology. 2023; 130(8):804-811. DOI: 10.1016/j.ophtha.2023.03.018. View

20.

Chen V, Ng M, Chiu W, McIntyre R, Lee Y, Lin T . Effects of selective serotonin reuptake inhibitors on glaucoma: A nationwide population-based study. PLoS One. 2017; 12(3):e0173005. PMC: 5336262. DOI: 10.1371/journal.pone.0173005. View