Health of Saudi Women in the Post-Pandemic Era: Incidence and Post COVID-19 and COVID-19-Vaccination

Overview

Journal Int J Womens Health

Publisher Dove Medical Press

Specialty Gynecology & Obstetrics

Date 2024 Oct 18

PMID 39421715

Authors

Sami A Alawfi

Affiliations

Soon will be listed here.

Abstract

Introduction: Candidiasis, commonly known as yeast infection, affects people worldwide due to the overgrowth of species. Of several types, genital candidiasis, particularly vulvovaginal candidiasis (VVC), primarily caused by is frequently observed in females of reproductive age. Candidiasis has also become a serious issue in the post-pandemic era, as it occurs as a secondary infection in COVID-19 patients during or after the course of viral illness. Therefore, this study investigated the incidence of infections in women of reproductive age, and its relationship with the incidence of COVID-19 and vaccination in Saudi Arabia.

Objective: Additionally, this study aimed to determine the awareness of women on candidiasis and its subsequent impact on the occurrence of infection. A survey-based quantitative study was conducted in which primary data were collected from participants using a self-reported questionnaire.

Methods: A total of 200 women aged 18-45 were selected through random sampling. Apart from their sociodemographic characteristics, the history of COVID-19 incidence, COVID-19 vaccination, and candidiasis occurrences among respondents were recorded. Their level of awareness and knowledge of candidiasis, along with their perceptions of strategies for mitigating the risk of incidence, were also evaluated. The collected data were analysed using different statistical tools.

Results: The findings of this study revealed a positive correlation between candidiasis, viral infection, and vaccination, regardless of the type and dosage of vaccine administered. Furthermore, both COVID-19 incidence and vaccination had a positive and significant impact on the occurrence of candidiasis among Saudi women.

Conclusion: Despite certain limitations, this study has theoretical and managerial implications for improved management of candidiasis in the post-COVID era.

References

Algaissi A, Alharbi N, Hassanain M, Hashem A . Preparedness and response to COVID-19 in Saudi Arabia: Building on MERS experience. J Infect Public Health. 2020; 13(6):834-838. PMC: 7211706. DOI: 10.1016/j.jiph.2020.04.016. View

Disha T, Haque F . Prevalence and Risk Factors of Vulvovaginal Candidosis during Pregnancy: A Review. Infect Dis Obstet Gynecol. 2022; 2022:6195712. PMC: 9329029. DOI: 10.1155/2022/6195712. View

Khan S, Bilal H, Khan M, Fang W, Chang W, Yin B . Interleukin inhibitors and the associated risk of candidiasis. Front Immunol. 2024; 15:1372693. PMC: 11007146. DOI: 10.3389/fimmu.2024.1372693. View

Papadimitriou-Olivgeris M, Spiliopoulou A, Kolonitsiou F, Bartzavali C, Lambropoulou A, Xaplanteri P . Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009-2017) in a university Greek hospital. Infection. 2018; 47(2):209-216. DOI: 10.1007/s15010-018-1217-2. View

Losier A, Gupta G, Caldararo M, Dela Cruz C . The Impact of Coronavirus Disease 2019 on Viral, Bacterial, and Fungal Respiratory Infections. Clin Chest Med. 2023; 44(2):407-423. PMC: 9968485. DOI: 10.1016/j.ccm.2022.11.018. View

Venugopal D, Husain K, Mustafa S, Sabeen S . Epidemiology, risk factors and antimicrobial profile of Vulvovaginal Candidiasis (VVC): A study among women in the central region of Saudi Arabia. J Mycol Med. 2020; 31(2):101049. DOI: 10.1016/j.mycmed.2020.101049. View

Beatty A, Peyser N, Butcher X, Cocohoba J, Lin F, Olgin J . Analysis of COVID-19 Vaccine Type and Adverse Effects Following Vaccination. JAMA Netw Open. 2021; 4(12):e2140364. PMC: 8696570. DOI: 10.1001/jamanetworkopen.2021.40364. View

Lamoth F, Lockhart S, Berkow E, Calandra T . Changes in the epidemiological landscape of invasive candidiasis. J Antimicrob Chemother. 2018; 73(suppl_1):i4-i13. DOI: 10.1093/jac/dkx444. View

Martins N, Ferreira I, Barros L, Silva S, Henriques M . Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment. Mycopathologia. 2014; 177(5-6):223-40. DOI: 10.1007/s11046-014-9749-1. View

10.

Denning D, Kneale M, Sobel J, Rautemaa-Richardson R . Global burden of recurrent vulvovaginal candidiasis: a systematic review. Lancet Infect Dis. 2018; 18(11):e339-e347. DOI: 10.1016/S1473-3099(18)30103-8. View

11.

Peman J, Ruiz-Gaitan A, Garcia-Vidal C, Salavert M, Ramirez P, Puchades F . Fungal co-infection in COVID-19 patients: Should we be concerned?. Rev Iberoam Micol. 2020; 37(2):41-46. PMC: 7489924. DOI: 10.1016/j.riam.2020.07.001. View

12.

Sonnweber T, Boehm A, Sahanic S, Pizzini A, Aichner M, Sonnweber B . Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients' performance: a prospective observational cohort study. Respir Res. 2020; 21(1):276. PMC: 7575703. DOI: 10.1186/s12931-020-01546-2. View

13.

Lass-Florl C, Steixner S . The changing epidemiology of fungal infections. Mol Aspects Med. 2023; 94:101215. DOI: 10.1016/j.mam.2023.101215. View

14.

Reddy G, Padmavathi A, Nancharaiah Y . Fungal infections: Pathogenesis, antifungals and alternate treatment approaches. Curr Res Microb Sci. 2022; 3:100137. PMC: 9325902. DOI: 10.1016/j.crmicr.2022.100137. View

15.

Arastehfar A, Shaban T, Zarrinfar H, Roudbary M, Ghazanfari M, Hedayati M . Candidemia among Iranian Patients with Severe COVID-19 Admitted to ICUs. J Fungi (Basel). 2021; 7(4). PMC: 8068363. DOI: 10.3390/jof7040280. View

16.

Chavda V, Mishra T, Kamaraj S, Punetha S, Sengupta O, Joshi Y . Post-COVID-19 Fungal Infection in the Aged Population. Vaccines (Basel). 2023; 11(3). PMC: 10056493. DOI: 10.3390/vaccines11030555. View

17.

Brown G, Denning D, Gow N, Levitz S, Netea M, White T . Hidden killers: human fungal infections. Sci Transl Med. 2012; 4(165):165rv13. DOI: 10.1126/scitranslmed.3004404. View

18.

Al Halteet S, Abdel-Hadi A, Hassan M, Awad M . Prevalence and Antifungal Susceptibility Profile of Clinically Relevant Species in Postmenopausal Women with Diabetes. Biomed Res Int. 2020; 2020:7042490. PMC: 7714583. DOI: 10.1155/2020/7042490. View

19.

Al-Hatmi A, Mohsin J, Al-Huraizi A, Khamis F . COVID-19 associated invasive candidiasis. J Infect. 2020; 82(2):e45-e46. PMC: 7411505. DOI: 10.1016/j.jinf.2020.08.005. View

20.

Achkar J, Fries B . Candida infections of the genitourinary tract. Clin Microbiol Rev. 2010; 23(2):253-73. PMC: 2863365. DOI: 10.1128/CMR.00076-09. View