Circ_0001047 Inhibits Prostate Cancer Progression and Enhances Abiraterone Sensitivity Via MiR-122-5p/FKBP5/PHLPP1/AKT Axis in Vitro

Overview

Journal Discov Oncol

Publisher Springer

Specialty Oncology

Date 2024 Oct 17

PMID 39419900

Authors

Zhenjie Chen

Shi Fu

Yiqian Shan

Zexi He

Jun Gu

Haichao Wu

Jiawei Lin

Yinglong Huang

Haifeng Wang

Yangbai Lu

Mingxia Ding

Affiliations

Soon will be listed here.

Abstract

Prostate cancer (PCa), with high heterogeneity and poor prognosis, is one of the most common malignant tumors in men. Circular RNAs (circRNAs) have been identified in tumor progression and resistance to medication in numerous studies. However, the role of circ_0001047 in PCa is unclear. In this research, we found that circ_0001047 had low expression in PCa cells and tissues and was negatively correlated with testosterone secretion in vivo. Overexpression of circ_0001047 inhibited the proliferation, migration, invasion, and anti-apoptotic abilities of human PCa cells in vitro. Mechanistically, circ_0001047 promoted the expression of FKBP5 through sponge adsorption of miR-122-5p and then inhibited the proliferation, anti-apoptotic migration, and invasion abilities of PCa cells. In addition, overexpression of circ_0001047 enhanced the sensitivity of PCa cells to abiraterone by inhibiting AKT phosphorylation activation through upregulation of FKBP5/PHLPP1. This study revealed a novel mechanism by which circ_0001047 regulates PCa progression and treatment sensitivity via the miR-122-5p/FKBP5/PHLPP1/AKT axis. These findings deepen our comprehension of the molecular mechanisms in latent PCa progression and treatment resistance.

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