Targeted Gold Nanoparticles for Ovarian Cancer (Review)

Overview

Journal Oncol Lett

Specialty Oncology

Date 2024 Oct 17

PMID 39417039

Authors

Wenjuan He

Fuyuan Yang

Keming Chen

Qingsong Zeng

Affiliations

Soon will be listed here.

Abstract

Among all malignant gynecological tumors, ovarian cancer (OC) has the highest mortality rate. OC is often diagnosed at advanced and incurable stages; however, early diagnosis can enable the use of optimized and personalized treatments. Intensive research into the synthesis and characterization of gold nanoparticles (AuNPs) has been performed with the aim of developing innovative materials for use in biological and photothermal therapies for OC. AuNPs can be chemically modified and functionalized by binding to a variety of organic compounds and biomolecules, such as peptides, antibodies and therapeutic agents, via simple synthetic processes. They are particularly suitable for use as carriers for drug delivery. In the present review, the synthesis and characteristics of AuNPs are summarized, and their potential in OC therapy are discussed.

References

Cui T, Liang J, Chen H, Geng D, Jiao L, Yang J . Performance of Doxorubicin-Conjugated Gold Nanoparticles: Regulation of Drug Location. ACS Appl Mater Interfaces. 2017; 9(10):8569-8580. DOI: 10.1021/acsami.6b16669. View

Rosi N, Giljohann D, Thaxton C, Lytton-Jean A, Han M, Mirkin C . Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science. 2006; 312(5776):1027-30. DOI: 10.1126/science.1125559. View

Omran B, Whitehead K, Baek K . One-pot bioinspired synthesis of fluorescent metal chalcogenide and carbon quantum dots: Applications and potential biotoxicity. Colloids Surf B Biointerfaces. 2021; 200:111578. DOI: 10.1016/j.colsurfb.2021.111578. View

Wood A, Sehgal C . A review of low-intensity ultrasound for cancer therapy. Ultrasound Med Biol. 2015; 41(4):905-28. PMC: 4362523. DOI: 10.1016/j.ultrasmedbio.2014.11.019. View

Schoutrop E, Moyano-Galceran L, Lheureux S, Mattsson J, Lehti K, Dahlstrand H . Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment. Semin Cancer Biol. 2022; 86(Pt 3):207-223. DOI: 10.1016/j.semcancer.2022.03.027. View

Zhou T, Du Y, Wei T . Transcriptomic analysis of human breast cancer cells reveals differentially expressed genes and related cellular functions and pathways in response to gold nanorods. Biophys Rep. 2016; 1:106-114. PMC: 4762141. DOI: 10.1007/s41048-015-0005-0. View

Spivak M, Bubnov R, Yemets I, Lazarenko L, Tymoshok N, Ulberg Z . Development and testing of gold nanoparticles for drug delivery and treatment of heart failure: a theranostic potential for PPP cardiology. EPMA J. 2013; 4(1):20. PMC: 3751918. DOI: 10.1186/1878-5085-4-20. View

Aziz F, Ihsan A, Nazir A, Ahmad I, Bajwa S, Rehman A . Novel route synthesis of porous and solid gold nanoparticles for investigating their comparative performance as contrast agent in computed tomography scan and effect on liver and kidney function. Int J Nanomedicine. 2017; 12:1555-1563. PMC: 5339011. DOI: 10.2147/IJN.S127996. View

Epanchintseva A, Poletaeva J, Pyshnyi D, Ryabchikova E, Pyshnaya I . Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions. Beilstein J Nanotechnol. 2020; 10:2568-2578. PMC: 6941443. DOI: 10.3762/bjnano.10.248. View

10.

Patil M, Kim G . Eco-friendly approach for nanoparticles synthesis and mechanism behind antibacterial activity of silver and anticancer activity of gold nanoparticles. Appl Microbiol Biotechnol. 2016; 101(1):79-92. DOI: 10.1007/s00253-016-8012-8. View

11.

Vargas-Molinero H, Serrano-Medina A, Palomino-Vizcaino K, Lopez-Maldonado E, Villarreal-Gomez L, Perez-Gonzalez G . Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems. Micromachines (Basel). 2023; 14(1). PMC: 9864385. DOI: 10.3390/mi14010208. View

12.

Hu X, Zhang Y, Ding T, Liu J, Zhao H . Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities. Front Bioeng Biotechnol. 2020; 8:990. PMC: 7438450. DOI: 10.3389/fbioe.2020.00990. View

13.

Piktel E, Oscilowska I, Suprewicz L, Depciuch J, Marcinczyk N, Chabielska E . ROS-Mediated Apoptosis and Autophagy in Ovarian Cancer Cells Treated with Peanut-Shaped Gold Nanoparticles. Int J Nanomedicine. 2021; 16:1993-2011. PMC: 7955786. DOI: 10.2147/IJN.S277014. View

14.

Patil M, Kim G . Marine microorganisms for synthesis of metallic nanoparticles and their biomedical applications. Colloids Surf B Biointerfaces. 2018; 172:487-495. DOI: 10.1016/j.colsurfb.2018.09.007. View

15.

Amina S, Guo B . A Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle. Int J Nanomedicine. 2020; 15:9823-9857. PMC: 7732174. DOI: 10.2147/IJN.S279094. View

16.

Huynh K, Pham X, Kim J, Lee S, Chang H, Rho W . Synthesis, Properties, and Biological Applications of Metallic Alloy Nanoparticles. Int J Mol Sci. 2020; 21(14). PMC: 7404399. DOI: 10.3390/ijms21145174. View

17.

Shen Y, Wang M, Wang H, Zhou J, Chen J . Multifunctional Human Serum Albumin Fusion Protein as a Docetaxel Nanocarrier for Chemo-photothermal Synergetic Therapy of Ovarian Cancer. ACS Appl Mater Interfaces. 2022; 14(17):19907-19917. DOI: 10.1021/acsami.2c03687. View

18.

Jabir M, Sahib U, Taqi Z, Taha A, Sulaiman G, Albukhaty S . Linalool-Loaded Glutathione-Modified Gold Nanoparticles Conjugated with CALNN Peptide as Apoptosis Inducer and NF-κB Translocation Inhibitor in SKOV-3 Cell Line. Int J Nanomedicine. 2020; 15:9025-9047. PMC: 7680166. DOI: 10.2147/IJN.S276714. View

19.

Mironava T, Hadjiargyrou M, Simon M, Jurukovski V, Rafailovich M . Gold nanoparticles cellular toxicity and recovery: effect of size, concentration and exposure time. Nanotoxicology. 2010; 4(1):120-37. DOI: 10.3109/17435390903471463. View

20.

Higbee-Dempsey E, Amirshaghaghi A, Case M, Bouche M, Kim J, Cormode D . Biodegradable Gold Nanoclusters with Improved Excretion Due to pH-Triggered Hydrophobic-to-Hydrophilic Transition. J Am Chem Soc. 2020; 142(17):7783-7794. PMC: 7238296. DOI: 10.1021/jacs.9b13813. View