The Molecular Mechanisms of Portal Vein Thrombosis in Hepatocellular Carcinoma

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2024 Oct 16

PMID 39409869

Authors

Linda Galasso

Lucia Cerrito

Fabrizio Termite

Irene Mignini

Giorgio Esposto

Raffaele Borriello

Maria Elena Ainora

Antonio Gasbarrini

Maria Assunta Zocco

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) represents the sixth most diagnosed cancer worldwide and is the second leading cause of cancer-related death in the world. The association of HCC and portal vein thrombosis (PVT) represents an advanced stage of the tumor. PVT has a prevalence of about 25-50% in HCC, determining poor prognosis and a remarkable reduction in therapeutic perspectives in these patients, leading to severe complications such as ascites, metastasis, an increase in portal hypertension and potentially fatal gastrointestinal bleeding. The aim of this review is to evaluate the molecular mechanisms that are at the basis of PVT development, trying to evaluate possible strategies in the early detection of patients at high risk of PVT.

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