The Immunomodulatory Effects of Selenium: A Journey from the Environment to the Human Immune System

Overview

Journal Nutrients

Date 2024 Oct 16

PMID 39408290

Authors

Rebecka A Sadler

Bonnie A Mallard

Umesh K Shandilya

Mohammed A Hachemi

Niel A Karrow

Affiliations

Soon will be listed here.

Abstract

Selenium (Se) is an essential nutrient that has gained attention for its impact on the human immune system. The purpose of this review is to explore Se's immunomodulatory properties and to make up-to-date information available so novel therapeutic applications may emerge. People acquire Se through dietary ingestion, supplementation, or nanoparticle applications. These forms of Se can beneficially modulate the immune system by enhancing antioxidant activity, optimizing the innate immune response, improving the adaptive immune response, and promoting healthy gut microbiota. Because of these many actions, Se supplementation can help prevent and treat pathogenic diseases, autoimmune diseases, and cancers. This review will discuss Se as a key micronutrient with versatile applications that supports disease management due to its beneficial immunomodulatory effects. Further research is warranted to determine safe dosing guidelines to avoid toxicity and refine the application of Se in medical treatments.

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References

Zhang Z, Xiang H, Sun G, Yang Y, Chen C, Li T . Effect of dietary selenium intake on gut microbiota in older population in Enshi region. Genes Environ. 2021; 43(1):56. PMC: 8667455. DOI: 10.1186/s41021-021-00220-3. View

Khazdouz M, Ebrahimi Daryani N, Cheraghpour M, Alborzi F, Hasani M, Ghavami S . The effect of selenium supplementation on disease activity and immune-inflammatory biomarkers in patients with mild-to-moderate ulcerative colitis: a randomized, double-blind, placebo-controlled clinical trial. Eur J Nutr. 2023; 62(8):3125-3134. DOI: 10.1007/s00394-023-03214-9. View

Jarmakiewicz-Czaja S, Ferenc K, Sokal-Dembowska A, Filip R . Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease. Int J Mol Sci. 2024; 25(8). PMC: 11050446. DOI: 10.3390/ijms25084390. View

Huang Z, Rose A, Hoffmann P . The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011; 16(7):705-43. PMC: 3277928. DOI: 10.1089/ars.2011.4145. View

Guillin O, Vindry C, Ohlmann T, Chavatte L . Selenium, Selenoproteins and Viral Infection. Nutrients. 2019; 11(9). PMC: 6769590. DOI: 10.3390/nu11092101. View

Shojadoost B, Taha-Abdelaziz K, Alkie T, Bekele-Yitbarek A, Barjesteh N, Laursen A . Supplemental dietary selenium enhances immune responses conferred by a vaccine against low pathogenicity avian influenza virus. Vet Immunol Immunopathol. 2020; 227:110089. DOI: 10.1016/j.vetimm.2020.110089. View

Combs Jr G . Biomarkers of selenium status. Nutrients. 2015; 7(4):2209-36. PMC: 4425141. DOI: 10.3390/nu7042209. View

Yang Z, Liu C, Liu C, Teng X, Li S . Selenium Deficiency Mainly Influences Antioxidant Selenoproteins Expression in Broiler Immune Organs. Biol Trace Elem Res. 2015; 172(1):209-221. DOI: 10.1007/s12011-015-0578-y. View

Zhang L, Chu C . Selenium Uptake, Transport, Metabolism, Reutilization, and Biofortification in Rice. Rice (N Y). 2022; 15(1):30. PMC: 9198118. DOI: 10.1186/s12284-022-00572-6. View

10.

Tieu S, Charchoglyan A, Wagter-Lesperance L, Karimi K, Bridle B, Karrow N . Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness. Nutrients. 2022; 14(19). PMC: 9571036. DOI: 10.3390/nu14194075. View

11.

Zang H, Qian S, Li J, Zhou Y, Zhu Q, Cui L . The effect of selenium on the autophagy of macrophage infected by Staphylococcus aureus. Int Immunopharmacol. 2020; 83:106406. DOI: 10.1016/j.intimp.2020.106406. View

12.

Combs Jr G . Selenium in global food systems. Br J Nutr. 2001; 85(5):517-47. DOI: 10.1079/bjn2000280. View

13.

Zheng D, Liwinski T, Elinav E . Interaction between microbiota and immunity in health and disease. Cell Res. 2020; 30(6):492-506. PMC: 7264227. DOI: 10.1038/s41422-020-0332-7. View

14.

Duffield A, Thomson C, Hill K, Williams S . An estimation of selenium requirements for New Zealanders. Am J Clin Nutr. 1999; 70(5):896-903. DOI: 10.1093/ajcn/70.5.896. View

15.

Dalia A, Loh T, Sazili A, Samsudin A . Influence of bacterial organic selenium on blood parameters, immune response, selenium retention and intestinal morphology of broiler chickens. BMC Vet Res. 2020; 16(1):365. PMC: 7526326. DOI: 10.1186/s12917-020-02587-x. View

16.

Su X, Wang Z, Li J, Gao S, Fan Y, Wang K . Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B. Virol J. 2024; 21(1):72. PMC: 10958902. DOI: 10.1186/s12985-024-02346-6. View

17.

Grebenciucova E, VanHaerents S . Interleukin 6: at the interface of human health and disease. Front Immunol. 2023; 14:1255533. PMC: 10569068. DOI: 10.3389/fimmu.2023.1255533. View

18.

Genchi G, Lauria G, Catalano A, Sinicropi M, Carocci A . Biological Activity of Selenium and Its Impact on Human Health. Int J Mol Sci. 2023; 24(3). PMC: 9917223. DOI: 10.3390/ijms24032633. View

19.

Silveira B, Rocha D, Martino H, Grancieri M, Gomes M, Mantovani H . Daily Cashew and Brazil Nut Consumption Modifies Intestinal Health in Overweight Women on Energy-Restricted Intervention: A Randomized Controlled Trial (Brazilian Nuts Study). J Nutr. 2024; 154(3):962-977. DOI: 10.1016/j.tjnut.2023.12.022. View

20.

Tamtaji O, Heidari-Soureshjani R, Mirhosseini N, Kouchaki E, Bahmani F, Aghadavod E . Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: A randomized, double-blind, controlled trial. Clin Nutr. 2019; 38(6):2569-2575. DOI: 10.1016/j.clnu.2018.11.034. View