Inflammasome-mediated Pyroptosis in Defense Against Pathogenic Bacteria

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2024 Oct 15

PMID 39404258

Authors

Changhoon Oh

Todd J Spears

Youssef Aachoui

Affiliations

Soon will be listed here.

Abstract

Macrophages, neutrophils, and epithelial cells are pivotal components of the host's immune response against bacterial infections. These cells employ inflammasomes to detect various microbial stimuli during infection, triggering an inflammatory response aimed at eradicating the pathogens. Among these inflammatory responses, pyroptosis, a lytic form of cell death, plays a crucial role in eliminating replicating bacteria and recruiting immune cells to combat the invading pathogen. The immunological function of pyroptosis varies across macrophages, neutrophils, and epithelial cells, aligning with their specific roles within the innate immune system. This review centers on elucidating the role of pyroptosis in resisting gram-negative bacterial infections, with a particular focus on the mechanisms at play in macrophages, neutrophils, and intestinal epithelial cells. Additionally, we underscore the cell type-specific roles of pyroptosis in vivo in these contexts during defense.

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